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Reversion-inducing-cysteine-rich protein with kazal motifs
Symbols RECK ; ST15
External IDs OMIM605227 MGI1855698 HomoloGene9622 GeneCards: RECK Gene
RNA expression pattern
PBB GE RECK 205407 at tn.png
More reference expression data
Species Human Mouse
Entrez 8434 53614
Ensembl ENSG00000122707 ENSMUSG00000028476
UniProt O95980 Q9Z0J1
RefSeq (mRNA) NM_021111 NM_016678
RefSeq (protein) NP_066934 NP_057887
Location (UCSC) Chr 9:
36.04 – 36.12 Mb
Chr 4:
43.88 – 43.94 Mb
PubMed search [1] [2]

Reversion-inducing-cysteine-rich protein with kazal motifs, also known as RECK, is a human gene,[1] thought to be a metastasis suppressor.

The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis.[1] It is one of the targets of an oncomiR, MIRN21.


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