RECK

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Reversion-inducing-cysteine-rich protein with kazal motifs
Identifiers
Symbols RECK ; ST15
External IDs OMIM605227 MGI1855698 HomoloGene9622 GeneCards: RECK Gene
RNA expression pattern
PBB GE RECK 205407 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8434 53614
Ensembl ENSG00000122707 ENSMUSG00000028476
UniProt O95980 Q9Z0J1
RefSeq (mRNA) NM_021111 NM_016678
RefSeq (protein) NP_066934 NP_057887
Location (UCSC) Chr 9:
36.04 – 36.12 Mb
Chr 4:
43.88 – 43.94 Mb
PubMed search [1] [2]

Reversion-inducing-cysteine-rich protein with kazal motifs, also known as RECK, is a human gene,[1] thought to be a metastasis suppressor.

The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis.[1] It is one of the targets of an oncomiR, MIRN21.

References[edit]

Further reading[edit]