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Regenerating islet-derived 1 alpha
Protein REG1A PDB 1lit.png
PDB rendering based on 1lit.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM167770 MGI97895 HomoloGene68282 GeneCards: REG1A Gene
RNA expression pattern
PBB GE REG1A 209752 at tn.png
More reference expression data
Species Human Mouse
Entrez 5967 19692
Ensembl ENSG00000115386 ENSMUSG00000059654
UniProt P05451 P43137
RefSeq (mRNA) NM_002909 NM_009042
RefSeq (protein) NP_002900 NP_033068
Location (UCSC) Chr 2:
79.35 – 79.35 Mb
Chr 6:
78.43 – 78.43 Mb
PubMed search [1] [2]

Lithostathine-1-alpha also known as islet cells regeneration factor (ICRF) or islet of Langerhans regenerating protein (REG) is a protein that in humans is encoded by the REG1A gene.[1][2][3]


This protein is a type I subclass member of the Regenerating protein family. The Reg protein family is a multi protein family grouped into four subclasses, types I, II, III and IV based on the primary structures of the proteins. This protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandomly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication.[3]


  1. ^ Watanabe T, Yonekura H, Terazono K, Yamamoto H, Okamoto H (Jun 1990). "Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The gene encode protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene". J Biol Chem 265 (13): 7432–9. PMID 2332435. 
  2. ^ Gharib B, Fox MF, Bartoli C, Giorgi D, Sansonetti A, Swallow DM, Dagorn JC, Berge-lefranc JL (Aug 1993). "Human regeneration protein/lithostathine genes map to chromosome 2p12". Ann Hum Genet 57 (Pt 1): 9–16. doi:10.1111/j.1469-1809.1993.tb00882.x. PMID 8333731. 
  3. ^ a b "Entrez Gene: REG1A regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein)". 

Further reading[edit]