REG3G

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Regenerating islet-derived 3 gamma
Identifiers
Symbols REG3G ; LPPM429; PAP IB; PAP-1B; PAP1B; PAPIB; REG III; REG-III; UNQ429
External IDs OMIM609933 MGI109408 HomoloGene128216 GeneCards: REG3G Gene
RNA expression pattern
PBB GE REG3G gnf1h03867 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 130120 19695
Ensembl ENSG00000143954 ENSMUSG00000030017
UniProt Q6UW15 O09049
RefSeq (mRNA) NM_001008387 NM_011260
RefSeq (protein) NP_001008388 NP_035390
Location (UCSC) Chr 2:
79.25 – 79.26 Mb
Chr 6:
78.47 – 78.47 Mb
PubMed search [1] [2]

Regenerating islet-derived protein 3 gamma is a protein that in humans is encoded by the REG3G gene.[1][2][3][4]

Intestinal paneth cells produce REG3G (or REG3 gamma) via stimulation of toll-like receptors (TLRs) by pathogen-associated molecular patterns (PAMPs). REG3 gamma specifically targets Gram-positive bacteria because it binds to their surface peptidoglycan layer. It is one of several antimicrobial peptides produced by paneth cells.[5]

Notes and references[edit]

  1. ^ Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. 
  2. ^ Nata K, Liu Y, Xu L, Ikeda T, Akiyama T, Noguchi N, Kawaguchi S, Yamauchi A, Takahashi I, Shervani NJ, Onogawa T, Takasawa S, Okamoto H (September 2004). "Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III". Gene 340 (1): 161–70. doi:10.1016/j.gene.2004.06.010. PMID 15556304. 
  3. ^ Laurine E, Manival X, Montgelard C, Bideau C, Bergé-Lefranc JL, Erard M, Verdier JM (March 2005). "PAP IB, a new member of the Reg gene family: cloning, expression, structural properties, and evolution by gene duplication". Biochim. Biophys. Acta 1727 (3): 177–87. doi:10.1016/j.bbaexp.2005.01.011. PMID 15777617. 
  4. ^ "Entrez Gene: REG3G regenerating islet-derived 3 gamma". 
  5. ^ Abreu MT (February 2010). "Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function". Nat. Rev. Immunol. 10 (2): 131–44. doi:10.1038/nri2707. PMID 20098461. 

Bibliography[edit]