RFX3

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Regulatory factor X, 3 (influences HLA class II expression)
Identifiers
Symbols RFX3 ; bA32F11.1
External IDs OMIM601337 MGI106582 HomoloGene7917 GeneCards: RFX3 Gene
RNA expression pattern
PBB GE RFX3 207234 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5991 19726
Ensembl ENSG00000080298 ENSMUSG00000040929
UniProt P48380 P48381
RefSeq (mRNA) NM_002919 NM_001166414
RefSeq (protein) NP_002910 NP_001159886
Location (UCSC) Chr 9:
3.22 – 3.53 Mb
Chr 19:
27.76 – 28.01 Mb
PubMed search [1] [2]

Transcription factor RFX3 is a protein that in humans is encoded by the RFX3 gene.[1][2]

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Two transcript variants encoding different isoforms have been described for this gene, and at least one of the variants utilizes alternative polyadenylation signals.[2]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.