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Regulator of G-protein signaling 1
Protein RGS1 PDB 2bv1.png
PDB rendering based on 2bv1.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RGS1 ; 1R20; BL34; HEL-S-87; IER1; IR20
External IDs OMIM600323 MGI1354694 HomoloGene2191 IUPHAR: 2804 GeneCards: RGS1 Gene
RNA expression pattern
PBB GE RGS1 216834 at tn.png
PBB GE RGS1 202988 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5996 50778
Ensembl ENSG00000090104 ENSMUSG00000026358
UniProt Q08116 Q9JL25
RefSeq (mRNA) NM_002922 NM_015811
RefSeq (protein) NP_002913 NP_056626
Location (UCSC) Chr 1:
192.54 – 192.55 Mb
Chr 1:
144.24 – 144.25 Mb
PubMed search [1] [2]

Regulator of G-protein signaling 1 is a protein that in humans is encoded by the RGS1 gene.[1][2][3]

This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.[3]


  1. ^ Newton JS, Deed RW, Mitchell EL, Murphy JJ, Norton JD (Jan 1994). "A B cell specific immediate early human gene is located on chromosome band 1q31 and encodes an alpha helical basic phosphoprotein". Biochim Biophys Acta 1216 (2): 314–6. doi:10.1016/0167-4781(93)90163-8. PMID 8241276. 
  2. ^ Druey KM, Blumer KJ, Kang VH, Kehrl JH (May 1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family". Nature 379 (6567): 742–6. doi:10.1038/379742a0. PMID 8602223. 
  3. ^ a b "Entrez Gene: RGS1 regulator of G-protein signalling 1". 

Further reading[edit]