Regulator of G-protein signaling 10 is a protein that in humans is encoded by the RGS10gene.
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene.
Tu Y, Popov S, Slaughter C, Ross EM (2000). "Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10.". J. Biol. Chem.274 (53): 38260–7. doi:10.1074/jbc.274.53.38260. PMID10608901.
Popov SG, Krishna UM, Falck JR, Wilkie TM (2000). "Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity.". J. Biol. Chem.275 (25): 18962–8. doi:10.1074/jbc.M001128200. PMID10747990.
Chatterjee TK, Fisher RA (2000). "Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs.". J. Biol. Chem.275 (31): 24013–21. doi:10.1074/jbc.M002082200. PMID10791963.
Burgon PG, Lee WL, Nixon AB et al. (2001). "Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10).". J. Biol. Chem.276 (35): 32828–34. doi:10.1074/jbc.M100960200. PMID11443111.CS1 maint: Explicit use of et al. (link)
Castro-Fernández C, Conn PM (2003). "Regulation of the gonadotropin-releasing hormone receptor (GnRHR) by RGS proteins: role of the GnRHR carboxyl-terminus.". Mol. Cell. Endocrinol.191 (2): 149–56. doi:10.1016/S0303-7207(02)00082-5. PMID12062898.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.CS1 maint: Explicit use of et al. (link)