From Wikipedia, the free encyclopedia
Jump to: navigation, search
Regulator of G-protein signaling 11
Symbols RGS11 ; RS11
External IDs OMIM603895 MGI1354739 HomoloGene77719 GeneCards: RGS11 Gene
RNA expression pattern
PBB GE RGS11 206107 at tn.png
PBB GE RGS11 211872 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8786 50782
Ensembl ENSG00000076344 ENSMUSG00000024186
UniProt O94810 G3X8W6
RefSeq (mRNA) NM_001286485 NM_001081069
RefSeq (protein) NP_001273414 NP_001074538
Location (UCSC) Chr 16:
0.32 – 0.33 Mb
Chr 17:
26.2 – 26.21 Mb
PubMed search [1] [2]

Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene.[1][2]

The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.[2]


  1. ^ Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP (Nov 1998). "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits". Proc Natl Acad Sci U S A 95 (22): 13307–12. doi:10.1073/pnas.95.22.13307. PMC 23793. PMID 9789084. 
  2. ^ a b "Entrez Gene: RGS11 regulator of G-protein signalling 11". 

Further reading[edit]