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Regulator of G-protein signaling 13
Symbols RGS13 ; MGC17173
External IDs OMIM607190 MGI2180585 HomoloGene14774 IUPHAR: 2805 GeneCards: RGS13 Gene
RNA expression pattern
PBB GE RGS13 210258 at tn.png
More reference expression data
Species Human Mouse
Entrez 6003 246709
Ensembl ENSG00000127074 ENSMUSG00000051079
UniProt O14921 Q8K443
RefSeq (mRNA) NM_002927 NM_153171
RefSeq (protein) NP_002918 NP_694811
Location (UCSC) Chr 1:
192.61 – 192.63 Mb
Chr 1:
144.14 – 144.18 Mb
PubMed search [1] [2]

Regulator of G-protein signaling 13 is a protein that in humans is encoded by the RGS13 gene.[1][2]

RGS 13 is a member of R4 subfamily of RGS (Regulators of G Protein Signaling) proteins which have only short peptide sequences flanking the RGS domain. RGS 13 suppresses the immunoglobulin E- mediated allergic responses.[3]

The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.[2]


  1. ^ Johnson EN, Druey KM (May 2002). "Functional characterization of the G protein regulator RGS13". J Biol Chem 277 (19): 16768–16774. doi:10.1074/jbc.M200751200. PMID 11875076. 
  2. ^ a b "Entrez Gene: RGS13 regulator of G-protein signalling 13". 
  3. ^ Bansal G, Xie Z, Rao S, Nocka KH, Druey KM (2008). "Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13". Nat. Immunol. 9 (1): 73–80. doi:10.1038/ni1533. PMC 2387203. PMID 18026105. 

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