RGS13

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Regulator of G-protein signaling 13
Identifiers
Symbols RGS13 ; MGC17173
External IDs OMIM607190 MGI2180585 HomoloGene14774 GeneCards: RGS13 Gene
RNA expression pattern
PBB GE RGS13 210258 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6003 246709
Ensembl ENSG00000127074 ENSMUSG00000051079
UniProt O14921 Q8K443
RefSeq (mRNA) NM_002927 NM_153171
RefSeq (protein) NP_002918 NP_694811
Location (UCSC) Chr 1:
192.61 – 192.63 Mb
Chr 1:
144.14 – 144.18 Mb
PubMed search [1] [2]

Regulator of G-protein signaling 13 is a protein that in humans is encoded by the RGS13 gene.[1][2]

RGS 13 is a member of R4 subfamily of RGS (Regualtors of G Protein Signaling) proteins which have only short peptide sequences flanking the RGS domain. RGS 13 suppresses the immunoglobulin E- mediated allergic responses.[3]

The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.[2]

References[edit]

  1. ^ Johnson EN, Druey KM (May 2002). "Functional characterization of the G protein regulator RGS13". J Biol Chem 277 (19): 16768–16774. doi:10.1074/jbc.M200751200. PMID 11875076. 
  2. ^ a b "Entrez Gene: RGS13 regulator of G-protein signalling 13". 
  3. ^ Bansal G, Xie Z, Rao S, Nocka KH, Druey KM (2008). "Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13". Nat. Immunol. 9 (1): 73–80. doi:10.1038/ni1533. PMC 2387203. PMID 18026105. 

Further reading[edit]

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