Regulator of G-protein signaling 13 is a protein that in humans is encoded by the RGS13gene.
RGS 13 is a member of R4 subfamily of RGS (Regulators of G Protein Signaling) proteins which have only short peptide sequences flanking the RGS domain. RGS 13 suppresses the immunoglobulin E- mediated allergic responses.
The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.
Gregory SG; Barlow KF; McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature441 (7091): 315–321. doi:10.1038/nature04727. PMID16710414.Cite uses deprecated parameter |author-separator= (help)
Han JI, Huang NN, Kim DU, Kehrl JH (2006). "RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization". J. Leukoc. Biol.79 (6): 1357–1368. doi:10.1189/jlb.1105693. PMID16565322.
Islam TC; Asplund AC; Lindvall JM et al. (2003). "High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma". Leukemia17 (9): 1880–1890. doi:10.1038/sj.leu.2403057. PMID12970790.Cite uses deprecated parameter |author-separator= (help)
Sierra DA; Gilbert DJ; Householder D et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics79 (2): 177–185. doi:10.1006/geno.2002.6693. PMID11829488.Cite uses deprecated parameter |author-separator= (help)
Druey KM, Blumer KJ, Kang VH, Kehrl JH (1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family". Nature379 (6567): 742–746. doi:10.1038/379742a0. PMID8602223.