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Regulator of G-protein signaling 16
Protein RGS16 PDB 2ik8.png
PDB rendering based on 2ik8.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RGS16 ; A28-RGS14; A28-RGS14P; RGS-R
External IDs OMIM602514 MGI108407 HomoloGene2196 GeneCards: RGS16 Gene
RNA expression pattern
PBB GE RGS16 209324 s at tn.png
PBB GE RGS16 209325 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6004 19734
Ensembl ENSG00000143333 ENSMUSG00000026475
UniProt O15492 P97428
RefSeq (mRNA) NM_002928 NM_011267
RefSeq (protein) NP_002919 NP_035397
Location (UCSC) Chr 1:
182.57 – 182.57 Mb
Chr 1:
153.74 – 153.75 Mb
PubMed search [1] [2]

Regulator of G-protein signaling 16 is a protein that in humans is encoded by the RGS16 gene.[1][2]

The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade.[2]


RGS16 has been shown to interact with GNAQ[3] and GNAI3.[4][5]


  1. ^ Snow BE, Antonio L, Suggs S, Siderovski DP (March 1998). "Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene". Gene 206 (2): 247–53. doi:10.1016/S0378-1119(97)00593-3. PMID 9469939. 
  2. ^ a b "Entrez Gene: RGS16 regulator of G-protein signalling 16". 
  3. ^ Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM (2003). "RGS16 inhibits signalling through the G alpha 13-Rho axis.". Nat Cell Biol 5 (12): 1095–103. doi:10.1038/ncb1065. PMID 14634662. 
  4. ^ Chen, C; Zheng B; Han J; Lin S C (March 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. Biol. Chem. (UNITED STATES) 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. ISSN 0021-9258. PMID 9079700. 
  5. ^ Beadling, C; Druey K M; Richter G; Kehrl J H; Smith K A (March 1999). "Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes". J. Immunol. (UNITED STATES) 162 (5): 2677–82. ISSN 0022-1767. PMID 10072511. 

Further reading[edit]