RGS18

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Regulator of G-protein signaling 18
Protein RGS18 PDB 2dlv.png
PDB rendering based on 2dlv.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RGS18 ; RGS13
External IDs OMIM607192 MGI1927498 HomoloGene11281 GeneCards: RGS18 Gene
RNA expression pattern
PBB GE RGS18 gnf1h08828 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 64407 64214
Ensembl ENSG00000150681 ENSMUSG00000026357
UniProt Q9NS28 Q99PG4
RefSeq (mRNA) NM_130782 NM_022881
RefSeq (protein) NP_570138 NP_075019
Location (UCSC) Chr 1:
192.13 – 192.15 Mb
Chr 1:
144.75 – 144.78 Mb
PubMed search [1] [2]

Regulator of G-protein signaling 18 is a protein that in humans is encoded by the RGS18 gene.[1][2]

This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[2]

Interactions[edit]

RGS18 has been shown to interact with GNAI3.[3][4]

References[edit]

  1. ^ Park IK, Klug CA, Li K, Jerabek L, Li L, Nanamori M, Neubig RR, Hood L, Weissman IL, Clarke MF (March 2001). "Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells". J Biol Chem 276 (2): 915–23. doi:10.1074/jbc.M005947200. PMID 11042171. 
  2. ^ a b "Entrez Gene: RGS18 regulator of G-protein signalling 18". 
  3. ^ Yowe, D; Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie T M, Gutierrez-Ramos C, Hodge M R (October 2001). "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes". Biochem. J. (England) 359 (Pt 1): 109–18. doi:10.1042/0264-6021:3590109. ISSN 0264-6021. PMC 1222126. PMID 11563974. 
  4. ^ Gagnon, Alison W; Murray David L; Leadley Robert J (July 2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cell. Signal. (England) 14 (7): 595–606. doi:10.1016/S0898-6568(02)00012-8. ISSN 0898-6568. PMID 11955952. 

Further reading[edit]