From Wikipedia, the free encyclopedia
Jump to: navigation, search
Regulator of G-protein signaling 18
Protein RGS18 PDB 2dlv.png
PDB rendering based on 2dlv.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RGS18 ; RGS13
External IDs OMIM607192 MGI1927498 HomoloGene11281 IUPHAR: 2807 GeneCards: RGS18 Gene
RNA expression pattern
PBB GE RGS18 gnf1h08828 at tn.png
More reference expression data
Species Human Mouse
Entrez 64407 64214
Ensembl ENSG00000150681 ENSMUSG00000026357
UniProt Q9NS28 Q99PG4
RefSeq (mRNA) NM_130782 NM_022881
RefSeq (protein) NP_570138 NP_075019
Location (UCSC) Chr 1:
192.13 – 192.15 Mb
Chr 1:
144.75 – 144.78 Mb
PubMed search [1] [2]

Regulator of G-protein signaling 18 is a protein that in humans is encoded by the RGS18 gene.[1][2]

This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[2]


RGS18 has been shown to interact with GNAI3.[3][4]


  1. ^ Park IK, Klug CA, Li K, Jerabek L, Li L, Nanamori M, Neubig RR, Hood L, Weissman IL, Clarke MF (March 2001). "Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells". J Biol Chem 276 (2): 915–23. doi:10.1074/jbc.M005947200. PMID 11042171. 
  2. ^ a b "Entrez Gene: RGS18 regulator of G-protein signalling 18". 
  3. ^ Yowe, D; Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie T M, Gutierrez-Ramos C, Hodge M R (October 2001). "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes". Biochem. J. (England) 359 (Pt 1): 109–18. doi:10.1042/0264-6021:3590109. ISSN 0264-6021. PMC 1222126. PMID 11563974. 
  4. ^ Gagnon, Alison W; Murray David L; Leadley Robert J (July 2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cell. Signal. (England) 14 (7): 595–606. doi:10.1016/S0898-6568(02)00012-8. ISSN 0898-6568. PMID 11955952. 

Further reading[edit]