RGS2

Regulator of G-protein signaling 2, 24kDa
PDB rendering based on 2af0.
Available structures PDB 2AF0, 2V4Z
Identifiers
Symbols	RGS2; G0S8
External IDs	OMIM: 600861 MGI: 1098271 HomoloGene: 2192 GeneCards: RGS2 Gene
Gene Ontology Molecular function • signal transducer activity • GTPase activator activity • protein binding • calmodulin binding Cellular component • nucleus • nucleolus • cytoplasm • mitochondrion • cytosol • plasma membrane • internal side of plasma membrane Biological process • regulation of translation • cell cycle • spermatogenesis • regulation of G-protein coupled receptor protein signaling pathway • negative regulation of phospholipase activity • negative regulation of cardiac muscle hypertrophy • negative regulation of MAP kinase activity • positive regulation of GTPase activity • positive regulation of GTPase activity • negative regulation of G-protein coupled receptor protein signaling pathway • brown fat cell differentiation • relaxation of cardiac muscle • positive regulation of cardiac muscle contraction • regulation of adrenergic receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5997	19735
Ensembl	ENSG00000116741	ENSMUSG00000026360
UniProt	P41220	O08849
RefSeq (mRNA)	NM_002923.3	NM_009061.4
RefSeq (protein)	NP_002914.1	NP_033087.2
Location (UCSC)	Chr 1: 192.78 – 192.78 Mb	Chr 1: 145.85 – 145.85 Mb
PubMed search	[1]	[2]

Regulator of G-protein signaling 2 is a protein that in humans is encoded by the RGS2 gene.

Interactions

RGS2 has been shown to interact with PRKG1 and ADCY5.

Further reading

• Siderovski DP, Blum S, Forsdyke RE, Forsdyke DR (1991). "A set of human putative lymphocyte G0/G1 switch genes includes genes homologous to rodent cytokine and zinc finger protein-encoding genes.". DNA Cell Biol. 9 (8): 579–87. doi:10.1089/dna.1990.9.579. PMID 1702972. 
• Wu HK, Heng HH, Shi XM, et al. (1995). "Differential expression of a basic helix-loop-helix phosphoprotein gene, G0S8, in acute leukemia and localization to human chromosome 1q31.". Leukemia 9 (8): 1291–8. PMID 7643615. 
• Druey KM, Blumer KJ, Kang VH, Kehrl JH (1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family.". Nature 379 (6567): 742–6. doi:10.1038/379742a0. PMID 8602223. 
• Siderovski DP, Hessel A, Chung S, et al. (1996). "A new family of regulators of G-protein-coupled receptors?". Curr. Biol. 6 (2): 211–2. doi:10.1016/S0960-9822(02)00454-2. PMID 8673468. 
• Heximer SP, Cristillo AD, Forsdyke DR (1997). "Comparison of mRNA expression of two regulators of G-protein signaling, RGS1/BL34/1R20 and RGS2/G0S8, in cultured human blood mononuclear cells.". DNA Cell Biol. 16 (5): 589–98. doi:10.1089/dna.1997.16.589. PMID 9174164. 
• Heximer SP, Watson N, Linder ME, et al. (1998). "RGS2/G0S8 is a selective inhibitor of Gqalpha function.". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14389–93. doi:10.1073/pnas.94.26.14389. PMC 24991. PMID 9405622. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=24991. 
• Tseng CC, Zhang XY (1998). "Role of regulator of G protein signaling in desensitization of the glucose-dependent insulinotropic peptide receptor.". Endocrinology 139 (11): 4470–5. doi:10.1210/en.139.11.4470. PMID 9794454. 
• Beadling C, Druey KM, Richter G, et al. (1999). "Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes.". J. Immunol. 162 (5): 2677–82. PMID 10072511. 
• Popov SG, Krishna UM, Falck JR, Wilkie TM (2000). "Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity.". J. Biol. Chem. 275 (25): 18962–8. doi:10.1074/jbc.M001128200. PMID 10747990. 
• Zheng B, Chen D, Farquhar MG (2000). "MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16.". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 3999–4004. doi:10.1073/pnas.97.8.3999. PMC 18131. PMID 10760272. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=18131. 
• Chatterjee TK, Fisher RA (2000). "Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs.". J. Biol. Chem. 275 (31): 24013–21. doi:10.1074/jbc.M002082200. PMID 10791963. 
• Sullivan BM, Harrison-Lavoie KJ, Marshansky V, et al. (2000). "RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport.". Mol. Biol. Cell 11 (9): 3155–68. PMC 14982. PMID 10982407. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=14982. 
• Cunningham ML, Waldo GL, Hollinger S, et al. (2001). "Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling.". J. Biol. Chem. 276 (8): 5438–44. doi:10.1074/jbc.M007699200. PMID 11063746. 
• Heximer SP, Lim H, Bernard JL, Blumer KJ (2001). "Mechanisms governing subcellular localization and function of human RGS2.". J. Biol. Chem. 276 (17): 14195–203. doi:10.1074/jbc.M009942200. PMID 11278586. 
• Mittmann C, Schüler C, Chung CH, et al. (2001). "Evidence for a short form of RGS3 preferentially expressed in the human heart.". Naunyn Schmiedebergs Arch. Pharmacol. 363 (4): 456–63. doi:10.1007/s002100000376. PMID 11330340. 
• Mittmann C, Chung CH, Höppner G, et al. (2002). "Expression of ten RGS proteins in human myocardium: functional characterization of an upregulation of RGS4 in heart failure.". Cardiovasc. Res. 55 (4): 778–86. doi:10.1016/S0008-6363(02)00459-5. PMID 12176127. 
• Nlend MC, Bookman RJ, Conner GE, Salathe M (2002). "Regulator of G-protein signaling protein 2 modulates purinergic calcium and ciliary beat frequency responses in airway epithelia.". Am. J. Respir. Cell Mol. Biol. 27 (4): 436–45. PMID 12356577. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Cho H, Harrison K, Schwartz O, Kehrl JH (2003). "The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signalling.". Biochem. J. 371 (Pt 3): 973–80. doi:10.1042/BJ20021769. PMC 1223344. PMID 12564955. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223344.