RGS20

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Regulator of G-protein signaling 20
Identifiers
Symbols RGS20 ; RGSZ1; ZGAP1
External IDs OMIM607193 MGI1929866 HomoloGene2745 GeneCards: RGS20 Gene
RNA expression pattern
PBB GE RGS20 210138 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8601 58175
Ensembl ENSG00000147509 ENSMUSG00000002459
UniProt O76081 Q9QZB1
RefSeq (mRNA) NM_003702 NM_001177795
RefSeq (protein) NP_003693 NP_001171266
Location (UCSC) Chr 8:
54.76 – 54.87 Mb
Chr 1:
4.91 – 5.07 Mb
PubMed search [1] [2]

Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene.[1][2][3]

Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM][3]

In melanocytic cells RGS20 gene expression may be regulated by MITF.[4]

Interactions[edit]

RGS20 has been shown to interact with GNAO1[5] and GNAZ.[1][6]

References[edit]

  1. ^ a b Glick JL, Meigs TE, Miron A, Casey PJ (Nov 1998). "RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha". J Biol Chem 273 (40): 26008–13. doi:10.1074/jbc.273.40.26008. PMID 9748279. 
  2. ^ Wang J, Ducret A, Tu Y, Kozasa T, Aebersold R, Ross EM (Nov 1998). "RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily". J Biol Chem 273 (40): 26014–25. doi:10.1074/jbc.273.40.26014. PMID 9748280. 
  3. ^ a b "Entrez Gene: RGS20 regulator of G-protein signalling 20". 
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  5. ^ Pagano, Mario; Jordan J Dedrick, Neves Susana R, Nguyen Tracy, Iyengar Ravi (Jun 2008). "Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways". Cell. Signal. (England) 20 (6): 1190–7. doi:10.1016/j.cellsig.2008.02.008. ISSN 0898-6568. PMC 3107604. PMID 18407463. 
  6. ^ Nagahama, Masami; Usui Shihomi, Shinohara Takashi, Yamaguchi Tomohiro, Tani Katsuko, Tagaya Mitsuo (Dec 2002). "Inactivation of Galpha(z) causes disassembly of the Golgi apparatus". J. Cell. Sci. (England) 115 (Pt 23): 4483–93. doi:10.1242/jcs.00093. ISSN 0021-9533. PMID 12414994. 

Further reading[edit]