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Regulator of G-protein signaling 20
Symbols RGS20 ; RGSZ1; ZGAP1; g(z)GAP; gz-GAP
External IDs OMIM607193 MGI1929866 HomoloGene2745 IUPHAR: 2803 GeneCards: RGS20 Gene
RNA expression pattern
PBB GE RGS20 210138 at tn.png
More reference expression data
Species Human Mouse
Entrez 8601 58175
Ensembl ENSG00000147509 ENSMUSG00000002459
UniProt O76081 Q9QZB1
RefSeq (mRNA) NM_001286673 NM_001177795
RefSeq (protein) NP_001273602 NP_001171266
Location (UCSC) Chr 8:
54.76 – 54.87 Mb
Chr 1:
4.91 – 5.07 Mb
PubMed search [1] [2]

Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene.[1][2][3]

Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM][3]

In melanocytic cells RGS20 gene expression may be regulated by MITF.[4]


RGS20 has been shown to interact with GNAO1[5] and GNAZ.[1][6]


  1. ^ a b Glick JL, Meigs TE, Miron A, Casey PJ (Nov 1998). "RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha". J Biol Chem 273 (40): 26008–13. doi:10.1074/jbc.273.40.26008. PMID 9748279. 
  2. ^ Wang J, Ducret A, Tu Y, Kozasa T, Aebersold R, Ross EM (Nov 1998). "RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily". J Biol Chem 273 (40): 26014–25. doi:10.1074/jbc.273.40.26014. PMID 9748280. 
  3. ^ a b "Entrez Gene: RGS20 regulator of G-protein signalling 20". 
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  5. ^ Pagano, Mario; Jordan J Dedrick; Neves Susana R; Nguyen Tracy; Iyengar Ravi (Jun 2008). "Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways". Cell. Signal. (England) 20 (6): 1190–7. doi:10.1016/j.cellsig.2008.02.008. ISSN 0898-6568. PMC 3107604. PMID 18407463. 
  6. ^ Nagahama, Masami; Usui Shihomi; Shinohara Takashi; Yamaguchi Tomohiro; Tani Katsuko; Tagaya Mitsuo (Dec 2002). "Inactivation of Galpha(z) causes disassembly of the Golgi apparatus". J. Cell. Sci. (England) 115 (Pt 23): 4483–93. doi:10.1242/jcs.00093. ISSN 0021-9533. PMID 12414994. 

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