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Regulator of G-protein signaling 3
Protein RGS3 PDB 2f5y.png
PDB rendering based on 2f5y.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RGS3 ; C2PA; RGP3
External IDs OMIM602189 MGI1354734 HomoloGene32440 IUPHAR: 2810 GeneCards: RGS3 Gene
RNA expression pattern
PBB GE RGS3 203823 at tn.png
PBB GE RGS3 220300 at tn.png
More reference expression data
Species Human Mouse
Entrez 5998 50780
Ensembl ENSG00000138835 ENSMUSG00000059810
UniProt P49796 Q9DC04
RefSeq (mRNA) NM_001276260 NM_001081650
RefSeq (protein) NP_001263189 NP_001075119
Location (UCSC) Chr 9:
116.21 – 116.36 Mb
Chr 4:
62.56 – 62.7 Mb
PubMed search [1] [2]

Regulator of G-protein signaling 3 is a protein that in humans is encoded by the RGS3 gene.[1][2][3]

This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known.[3]


  1. ^ Druey KM, Blumer KJ, Kang VH, Kehrl JH (May 1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family". Nature 379 (6567): 742–6. doi:10.1038/379742a0. PMID 8602223. 
  2. ^ Linares JL, Wendling C, Tomasetto C, Rio MC (Nov 2000). "C2PA, a new protein expressed during mouse spermatogenesis". FEBS Lett 480 (2–3): 249–54. doi:10.1016/S0014-5793(00)01942-6. PMID 11034339. 
  3. ^ a b "Entrez Gene: RGS3 regulator of G-protein signalling 3". 

Further reading[edit]