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Regulator of G-protein signaling 5
Protein RGS5 PDB 2crp.png
PDB rendering based on 2crp.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RGS5 ; MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129
External IDs OMIM603276 MGI1098434 HomoloGene2682 GeneCards: RGS5 Gene
RNA expression pattern
PBB GE RGS5 209071 s at tn.png
PBB GE RGS5 218353 at tn.png
PBB GE RGS5 209070 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8490 19737
Ensembl ENSG00000143248 ENSMUSG00000026678
UniProt O15539 O08850
RefSeq (mRNA) NM_001195303 NM_009063
RefSeq (protein) NP_001182232 NP_033089
Location (UCSC) Chr 1:
163.08 – 163.19 Mb
Chr 1:
169.66 – 169.7 Mb
PubMed search [1] [2]

Regulator of G-protein signaling 5 is a protein that in humans is encoded by the RGS5 gene.[1][2]

The regulator of G protein signaling (RGS) proteins are signal transduction molecules that have structural homology to SST2 of Saccharomyces cerevisiae and EGL-10 of Caenorhabditis elegans. Multiple genes homologous to SST2 are present in higher eukaryotes. RGS proteins are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators.[supplied by OMIM][2]


RGS5 has been shown to interact with GNAO1,[3][4] GNAI2[3][4] and GNAI3.[3][4]


  1. ^ Seki N, Sugano S, Suzuki Y, Nakagawara A, Ohira M, Muramatsu M, Saito T, Hori T (October 1998). "Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene". J Hum Genet 43 (3): 202–5. doi:10.1007/s100380050071. PMID 9747037. 
  2. ^ a b "Entrez Gene: RGS5 regulator of G-protein signalling 5". 
  3. ^ a b c Chen, C; Zheng B, Han J, Lin S C (March 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. Biol. Chem. (UNITED STATES) 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. ISSN 0021-9258. PMID 9079700. 
  4. ^ a b c Zhou, J; Moroi K, Nishiyama M, Usui H, Seki N, Ishida J, Fukamizu A, Kimura S (February 2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sci. (England) 68 (13): 1457–69. doi:10.1016/S0024-3205(01)00939-0. ISSN 0024-3205. PMID 11253162. 

Further reading[edit]