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Regulator of G-protein signaling 7
Protein RGS7 PDB 2a72.png
PDB rendering based on 2a72.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol RGS7
External IDs OMIM602517 MGI1346089 HomoloGene2193 GeneCards: RGS7 Gene
RNA expression pattern
PBB GE RGS7 206290 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6000 24012
Ensembl ENSG00000182901 ENSMUSG00000026527
UniProt P49802 O54829
RefSeq (mRNA) NM_001282773 NM_001199003
RefSeq (protein) NP_001269702 NP_001185932
Location (UCSC) Chr 1:
240.93 – 241.52 Mb
Chr 1:
175.06 – 175.49 Mb
PubMed search [1] [2]

Regulator of G-protein signaling 7 is a protein that in humans is encoded by the RGS7 gene.[1][2]

RGS7 is highly enriched in the brain where it acts as a universal inhibitor of Gi/o-coupled GPCR. RGS7 is a GTPase-activating protein (GAP). It accelerates the GTP hydrolysis on G proteins determining their fast inactivation and acting as intracellular antagonists of GPCR signaling.[3]


RGS7 has been shown to interact with GPR158,[4] PKD1,[5] GNB5[6][7] and SNAPAP.[8]


  1. ^ Koelle MR, Horvitz HR (Feb 1996). "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins". Cell 84 (1): 115–25. doi:10.1016/S0092-8674(00)80998-8. PMID 8548815. 
  2. ^ "Entrez Gene: RGS7 regulator of G-protein signalling 7". 
  3. ^ Anderson, Garret R.; Ekaterina Posokhova; Kirill A. Martemyanov (July 2009). "The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling". Cell Biochemistry and Biophysics 54 (1-3): 33-46. doi:10.1007/s12013-009-9052-9. PMC 2827338. PMID 19521673. 
  4. ^ Orlandi, Cesare; Ekaterina Posokhova; Ikuo Masuho; Thomas A. Ray; Nazarul Hasan; Ronald G. Gregg; Kirill A. Martemyanov (June 11, 2012). "GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes". Journal of Cell Biology 197 (6): 711-719. doi:10.1083/jcb.201202123. PMC 3373406. PMID 22689652. 
  5. ^ Kim, E; Arnould T; Sellin L; Benzing T; Comella N; Kocher O; Tsiokas L; Sukhatme V P; Walz G (May 1999). "Interaction between RGS7 and polycystin". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (11): 6371–6. doi:10.1073/pnas.96.11.6371. ISSN 0027-8424. PMC 26888. PMID 10339594. 
  6. ^ Levay, K; Cabrera J L; Satpaev D K; Slepak V Z (Mar 1999). "Gβ5 prevents the RGS7-Gαo interaction through binding to a distinct Gγ-like domain found in RGS7 and other RGS proteins". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (5): 2503–7. doi:10.1073/pnas.96.5.2503. ISSN 0027-8424. PMC 26814. PMID 10051672. 
  7. ^ Posner, B A; Gilman A G; Harris B A (Oct 1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways". J. Biol. Chem. (UNITED STATES) 274 (43): 31087–93. doi:10.1074/jbc.274.43.31087. ISSN 0021-9258. PMID 10521509. 
  8. ^ Hunt, Rachel A; Edris Wade; Chanda Pranab K; Nieuwenhuijsen Bart; Young Kathleen H (Apr 2003). "Snapin interacts with the N-terminus of regulator of G protein signaling 7". Biochem. Biophys. Res. Commun. (United States) 303 (2): 594–9. doi:10.1016/S0006-291X(03)00400-5. ISSN 0006-291X. PMID 12659861. 

Further reading[edit]