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Regulator of G-protein signaling 8
Protein RGS8 PDB 2ihd.png
PDB rendering based on 2ihd.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RGS8 ; MGC119067; MGC119068; MGC119069
External IDs OMIM607189 HomoloGene23152 IUPHAR: 2813 GeneCards: RGS8 Gene
Species Human Mouse
Entrez 85397 67792
Ensembl ENSG00000135824 ENSMUSG00000042671
UniProt P57771 Q8BXT1
RefSeq (mRNA) NM_001102450 NM_026380
RefSeq (protein) NP_001095920 NP_080656
Location (UCSC) Chr 1:
182.62 – 182.65 Mb
Chr 1:
153.65 – 153.7 Mb
PubMed search [1] [2]

Regulator of G-protein signaling 8 is a protein that in humans is encoded by the RGS8 gene.[1][2]

This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation.[2]


  1. ^ Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, Morgenbesser SD, Su K, Faruque MU, Pinkett H, Graham C, Baxevanis AD, Klinger KW, Landes GM, Trent JM, Carpten JD (Apr 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611. 
  2. ^ a b "Entrez Gene: RGS8 regulator of G-protein signalling 8". 

Further reading[edit]