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Rho-related BTB domain containing 3
Symbols RHOBTB3 ; KIAA0878
External IDs OMIM607353 MGI1920546 HomoloGene8932 GeneCards: RHOBTB3 Gene
RNA expression pattern
PBB GE RHOBTB3 202975 s at tn.png
PBB GE RHOBTB3 202976 s at tn.png
PBB GE RHOBTB3 216048 s at tn.png
More reference expression data
Species Human Mouse
Entrez 22836 73296
Ensembl ENSG00000164292 ENSMUSG00000021589
UniProt O94955 Q9CTN4
RefSeq (mRNA) NM_014899 NM_028493
RefSeq (protein) NP_055714 NP_082769
Location (UCSC) Chr 5:
95.05 – 95.16 Mb
Chr 13:
75.87 – 75.94 Mb
PubMed search [1] [2]

Rho-related BTB domain-containing protein 3 is a protein that in humans is encoded by the RHOBTB3 gene.[1][2][3]

RHOBTB3 is a member of the evolutionarily conserved RhoBTB subfamily of Rho GTPases. For background information on RHOBTBs, see RHOBTB1 (MIM 607351).[supplied by OMIM][3]

Model organisms[edit]

Model organisms have been used in the study of RHOBTB3 function. A conditional knockout mouse line, called Rhobtb3tm1a(KOMP)Wtsi[11][12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[13][14][15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][16] Twenty three tests were carried out on mutant mice and four significant abnormalities were observed.[9] Homozygote mutant males had a decreased body weight and abnormal tooth morphology; females had decreased forepaw grip strength and both sexes had a decreased body length.[9]


  1. ^ Rivero F, Dislich H, Glockner G, Noegel AA (Mar 2001). "The Dictyostelium discoideum family of Rho-related proteins". Nucleic Acids Res 29 (5): 1068–79. doi:10.1093/nar/29.5.1068. PMC 29714. PMID 11222756. 
  2. ^ Boureux A, Vignal E, Faure S, Fort P (Dec 2006). "Evolution of the Rho family of ras-like GTPases in eukaryotes". Mol Biol Evol 24 (1): 203–16. doi:10.1093/molbev/msl145. PMC 2665304. PMID 17035353. 
  3. ^ a b "Entrez Gene: RHOBTB3 Rho-related BTB domain containing 3". 
  4. ^ "Body weight data for Rhobtb3". Wellcome Trust Sanger Institute. 
  5. ^ "Grip strength data for Rhobtb3". Wellcome Trust Sanger Institute. 
  6. ^ "DEXA data for Rhobtb3". Wellcome Trust Sanger Institute. 
  7. ^ "Radiography data for Rhobtb3". Wellcome Trust Sanger Institute. 
  8. ^ "Citrobacter infection data for Rhobtb3". Wellcome Trust Sanger Institute. 
  9. ^ a b c d Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  10. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  11. ^ "International Knockout Mouse Consortium". 
  12. ^ "Mouse Genome Informatics". 
  13. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.  edit
  14. ^ Dolgin E (2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  15. ^ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  16. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353. 

Further reading[edit]