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Ras homolog family member Q
Protein RHOQ PDB 2atx.png
PDB rendering based on 2atx.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RHOQ ; ARHQ; HEL-S-42; RASL7A; TC10; TC10A
External IDs OMIM605857 MGI1931553 HomoloGene22704 GeneCards: RHOQ Gene
RNA expression pattern
PBB GE RHOQ 212120 at tn.png
PBB GE RHOQ 214449 s at tn.png
PBB GE RHOQ 212117 at tn.png
More reference expression data
Species Human Mouse
Entrez 23433 104215
Ensembl ENSG00000119729 ENSMUSG00000024143
UniProt P17081 Q8R527
RefSeq (mRNA) NM_012249 NM_145491
RefSeq (protein) NP_036381 NP_663466
Location (UCSC) Chr 2:
46.77 – 46.81 Mb
Chr 17:
86.96 – 87 Mb
PubMed search [1] [2]

Rho-related GTP-binding protein RhoQ is a protein that in humans is encoded by the RHOQ gene.[1][2]

TC10 is a member of the RAS superfamily of small GTP-binding proteins (see HRAS, MIM 190020) involved in insulin-stimulated glucose uptake.[supplied by OMIM][2]

In melanocytic cells RHOQ gene expression may be regulated by MITF.[3]


RHOQ has been shown to interact with EXOC7,[4] GOPC,[5] PARD6B,[5][6] WASL,[7] CDC42EP2,[8] TRIP10[9] and CDC42EP3.[8]


  1. ^ Drivas GT, Shih A, Coutavas E, Rush MG, D'Eustachio P (May 1990). "Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line". Mol Cell Biol 10 (4): 1793–8. PMC 362288. PMID 2108320. 
  2. ^ a b "Entrez Gene: RHOQ ras homolog gene family, member Q". 
  3. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  4. ^ Inoue, Mayumi; Chang Louise; Hwang Joseph; Chiang Shian-Huey; Saltiel Alan R (April 2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin". Nature (England) 422 (6932): 629–33. doi:10.1038/nature01533. ISSN 0028-0836. PMID 12687004. 
  5. ^ a b Neudauer, C L; Joberty G; Macara I G (January 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem. Biophys. Res. Commun. (United States) 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. ISSN 0006-291X. PMID 11162552. 
  6. ^ Joberty, G; Petersen C; Gao L; Macara I G (August 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. (ENGLAND) 2 (8): 531–9. doi:10.1038/35019573. ISSN 1465-7392. PMID 10934474. 
  7. ^ Abe, Tomoyuki; Kato Masayoshi; Miki Hiroaki; Takenawa Tadaomi; Endo Takeshi (January 2003). "Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth". J. Cell. Sci. (England) 116 (Pt 1): 155–68. doi:10.1242/jcs.00208. ISSN 0021-9533. PMID 12456725. 
  8. ^ a b Joberty, G; Perlungher R R; Macara I G (October 1999). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Mol. Cell. Biol. (UNITED STATES) 19 (10): 6585–97. ISSN 0270-7306. PMC 84628. PMID 10490598. 
  9. ^ Chang, Louise; Adams Rachael D; Saltiel Alan R (October 2002). "The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (20): 12835–40. doi:10.1073/pnas.202495599. ISSN 0027-8424. PMC 130546. PMID 12242347. 

Further reading[edit]