From Wikipedia, the free encyclopedia
Jump to: navigation, search
Ras homolog family member T1
Symbols RHOT1 ; ARHT1; MIRO-1; MIRO1
External IDs OMIM613888 MGI1926078 HomoloGene56803 GeneCards: RHOT1 Gene
RNA expression pattern
PBB GE RHOT1 218323 at tn.png
PBB GE RHOT1 222148 s at tn.png
More reference expression data
Species Human Mouse
Entrez 55288 59040
Ensembl ENSG00000126858 ENSMUSG00000017686
UniProt Q8IXI2 Q8BG51
RefSeq (mRNA) NM_001033566 NM_001163354
RefSeq (protein) NP_001028738 NP_001156826
Location (UCSC) Chr 17:
30.47 – 30.58 Mb
Chr 11:
80.21 – 80.27 Mb
PubMed search [1] [2]

Mitochondrial Rho GTPase 1 is an enzyme that in humans is encoded by the RHOT1 gene.[1][2]

Model organisms[edit]

Model organisms have been used in the study of RHOT1 function. A conditional knockout mouse line, called Rhot1tm1a(EUCOMM)Wtsi[7][8] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[9][10][11]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5][12] Twenty six tests were carried out on mutant mice and one significant abnormality was observed: no homozygous mutants survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice and no further abnormalities were observed.[5]


  1. ^ Fransson A, Ruusala A, Aspenstrom P (Feb 2003). "Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis". J Biol Chem 278 (8): 6495–502. doi:10.1074/jbc.M208609200. PMID 12482879. 
  2. ^ "Entrez Gene: RHOT1 ras homolog gene family, member T1". 
  3. ^ "Salmonella infection data for Rhot1". Wellcome Trust Sanger Institute. 
  4. ^ "Citrobacter infection data for Rhot1". Wellcome Trust Sanger Institute. 
  5. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  6. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  7. ^ "International Knockout Mouse Consortium". 
  8. ^ "Mouse Genome Informatics". 
  9. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.  edit
  10. ^ Dolgin E (2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  11. ^ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  12. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353. 

Further reading[edit]