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Ras homolog family member T2
Symbols RHOT2 ; ARHT2; C16orf39; MIRO-2; MIRO2; RASL
External IDs OMIM613889 MGI2384892 HomoloGene56038 GeneCards: RHOT2 Gene
EC number 3.6.5.-
RNA expression pattern
PBB GE RHOT2 221789 x at tn.png
PBB GE RHOT2 222131 x at tn.png
PBB GE RHOT2 65770 at tn.png
More reference expression data
Species Human Mouse
Entrez 89941 214952
Ensembl ENSG00000140983 ENSMUSG00000025733
UniProt Q8IXI1 Q8JZN7
RefSeq (mRNA) NM_138769 NM_145999
RefSeq (protein) NP_620124 NP_666111
Location (UCSC) Chr 16:
0.72 – 0.72 Mb
Chr 17:
25.84 – 25.84 Mb
PubMed search [1] [2]

Mitochondrial Rho GTPase 2 is an enzyme that in humans is encoded by the RHOT2 gene.[1][2]


The gene homolog of RHOT2 in yeast codes for a protein called Gem1 that has been shown to be part of a complex of proteins that functions at points of contact between the endoplasmic reticulum and mitochondria.[3]


  1. ^ Fransson A, Ruusala A, Aspenstrom P (Feb 2003). "Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis". J Biol Chem 278 (8): 6495–502. doi:10.1074/jbc.M208609200. PMID 12482879. 
  2. ^ "Entrez Gene: RHOT2 ras homolog gene family, member T2". 
  3. ^ Kornmann, B.; Osman, C.; Walter, P. (2011). "The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections". Proceedings of the National Academy of Sciences 108 (34): 14151–14156. doi:10.1073/pnas.1111314108. PMC 3161550. PMID 21825164.  edit

Further reading[edit]