From Wikipedia, the free encyclopedia
Jump to: navigation, search
Regulating synaptic membrane exocytosis 1
Protein RIMS1 PDB 1zub.png
PDB rendering based on 1zub.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RIMS1 ; CORD7; RAB3IP2; RIM; RIM1
External IDs OMIM606629 HomoloGene128399 GeneCards: RIMS1 Gene
RNA expression pattern
PBB GE RIMS1 216184 s at tn.png
More reference expression data
Species Human Mouse
Entrez 22999 116837
Ensembl ENSG00000079841 n/a
UniProt Q86UR5 Q99NE5
RefSeq (mRNA) NM_001168407 NM_001012623
RefSeq (protein) NP_001161879 NP_001012641
Location (UCSC) Chr 6:
72.6 – 73.11 Mb
PubMed search [1] [2]

Regulating synaptic membrane exocytosis protein 1 is a protein that in humans is encoded by the RIMS1 gene.[1][2][3]

RAB3A (MIM 179490), a member of the Ras superfamily of genes, is a synaptic vesicle protein that regulates synaptic vesicle exocytosis. MUNC13 (UNC13; MIM 605836) and its isoforms are required for priming synaptic vesicles for exocytosis. The RIM family of active zone proteins likely function as protein scaffolds that help regulate vesicle exocytosis during short-term plasticity.[supplied by OMIM][3]


RIMS1 has been shown to interact with UNC13B,[4][5] RAB3A,[4][6] ERC2[5][7] and YWHAH.[8]


  1. ^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (September 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841. 
  2. ^ Coppola T, Magnin-Luthi S, Perret-Menoud V, Gattesco S, Schiavo G, Regazzi R (August 2001). "Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin". J Biol Chem 276 (35): 32756–62. doi:10.1074/jbc.M100929200. PMID 11438518. 
  3. ^ a b "Entrez Gene: RIMS1 regulating synaptic membrane exocytosis 1". 
  4. ^ a b Betz, A; Thakur P; Junge H J; Ashery U; Rhee J S; Scheuss V; Rosenmund C; Rettig J; Brose N (April 2001). "Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming". Neuron (United States) 30 (1): 183–96. doi:10.1016/S0896-6273(01)00272-0. ISSN 0896-6273. PMID 11343654. 
  5. ^ a b Ohtsuka, Toshihisa; Takao-Rikitsu Etsuko, Inoue Eiji, Inoue Marie, Takeuchi Masakazu, Matsubara Kaho, Deguchi-Tawarada Maki, Satoh Keiko, Morimoto Koji, Nakanishi Hiroyuki, Takai Yoshimi (August 2002). "Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1". J. Cell Biol. (United States) 158 (3): 577–90. doi:10.1083/jcb.200202083. ISSN 0021-9525. PMC 2173811. PMID 12163476. 
  6. ^ Fukuda, Mitsunori (April 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J. Biol. Chem. (United States) 278 (17): 15373–80. doi:10.1074/jbc.M212341200. ISSN 0021-9258. PMID 12578829. 
  7. ^ Takao-Rikitsu, Etsuko; Mochida Sumiko, Inoue Eiji, Deguchi-Tawarada Maki, Inoue Marie, Ohtsuka Toshihisa, Takai Yoshimi (January 2004). "Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release". J. Cell Biol. (United States) 164 (2): 301–11. doi:10.1083/jcb.200307101. ISSN 0021-9525. PMC 2172332. PMID 14734538. 
  8. ^ Sun, Lei; Bittner Mary A; Holz Ronald W (October 2003). "Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus". J. Biol. Chem. (United States) 278 (40): 38301–9. doi:10.1074/jbc.M212801200. ISSN 0021-9258. PMID 12871946. 

Further reading[edit]