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Regulating synaptic membrane exocytosis 2
Protein RIMS2 PDB 1v27.png
PDB rendering based on 1v27.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RIMS2 ; OBOE; RAB3IP3; RIM2
External IDs OMIM606630 HomoloGene81639 GeneCards: RIMS2 Gene
RNA expression pattern
PBB GE RIMS2 206137 at tn.png
More reference expression data
Species Human Mouse
Entrez 9699 116838
Ensembl ENSG00000176406 ENSMUSG00000037386
UniProt Q9UQ26 Q9EQZ7
RefSeq (mRNA) NM_001100117 NM_001256382
RefSeq (protein) NP_001093587 NP_001243311
Location (UCSC) Chr 8:
104.51 – 105.27 Mb
Chr 15:
39.2 – 39.68 Mb
PubMed search [1] [2]

Regulating synaptic membrane exocytosis protein 2 is a protein that in humans is encoded by the RIMS2 gene.[1][2][3]


RIMS2 has been shown to interact with YWHAH[4] and RAPGEF4.[5][6]


  1. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (April 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452. 
  2. ^ Fukuda M (April 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J Biol Chem 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829. 
  3. ^ "Entrez Gene: RIMS2 regulating synaptic membrane exocytosis 2". 
  4. ^ Sun, Lei; Bittner Mary A; Holz Ronald W (October 2003). "Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus". J. Biol. Chem. (United States) 278 (40): 38301–9. doi:10.1074/jbc.M212801200. ISSN 0021-9258. PMID 12871946. 
  5. ^ Shibasaki, Tadao; Sunaga Yasuhiro; Fujimoto Kei; Kashima Yasushige; Seino Susumu (February 2004). "Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis". J. Biol. Chem. (United States) 279 (9): 7956–61. doi:10.1074/jbc.M309068200. ISSN 0021-9258. PMID 14660679. 
  6. ^ Kashima, Y; Miki T; Shibasaki T; Ozaki N; Miyazaki M; Yano H; Seino S (Dec 2001). "Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion". J. Biol. Chem. (United States) 276 (49): 46046–53. doi:10.1074/jbc.M108378200. ISSN 0021-9258. PMID 11598134. 

Further reading[edit]