RIN1

Ras and Rab interactor 1
Identifiers
Symbols	RIN1;
External IDs	OMIM: 605965 MGI: 2385695 HomoloGene: 3170 GeneCards: RIN1 Gene
Gene Ontology Molecular function • GTPase activator activity • protein binding Cellular component • cytoplasm • cytoskeleton • plasma membrane Biological process • endocytosis • signal transduction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9610	225870
Ensembl	ENSG00000174791	ENSMUSG00000024883
UniProt	Q13671	Q921Q7
RefSeq (mRNA)	NM_004292	NM_145495.2
RefSeq (protein)	NP_004283	NP_663470.1
Location (UCSC)	Chr 11: 66.1 – 66.1 Mb	Chr 19: 5.05 – 5.06 Mb
PubMed search	[1]	[2]

Ras and Rab interactor 1 is a protein that in humans is encoded by the RIN1 gene.

Interactions

RIN1 has been shown to interact with HRAS.

Additionally, RIN1 binds and activates ABL family tyrosine kinases.

Further reading

• Dkaha A, Costa RM, Hu H, Irvin DK, Patel A, Kornblum HI, Silva AJ, O'Dell TJ, Colicelli J (2003). "The RAS effector RIN1 modulates the formation of aversive memories". J. Neurosci. 23 (3): 748–757. PMID 12574403. 

• Trowbridge IS, Lesley J, Trotter J, Hyman R (1985). "Thymocyte subpopulation enriched for progenitors with an unrearranged T-cell receptor beta-chain gene". Nature 315 (6021): 666–9. doi:10.1038/315666a0. PMID 3874369. 
• Han L, Colicelli J (1995). "A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1". Mol. Cell. Biol. 15 (3): 1318–23. PMC 230355. PMID 7862125. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=230355. 
• Afar DE, Han L, McLaughlin J et al (1997). "Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1". Immunity 6 (6): 773–82. doi:10.1016/S1074-7613(00)80452-5. PMID 9208849. 
• Tall GG, Barbieri MA, Stahl PD, Horazdovsky BF (2001). "Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1". Dev. Cell 1 (1): 73–82. doi:10.1016/S1534-5807(01)00008-9. PMID 11703925. 
• Wang Y, Waldron RT, Dhaka A et al (2002). "The RAS Effector RIN1 Directly Competes with RAF and Is Regulated by 14-3-3 Proteins". Mol. Cell. Biol. 22 (3): 916–26. doi:10.1128/MCB.22.3.916-926.2001. PMC 133556. PMID 11784866. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133556. 
• Murphy GA, Graham SM, Morita S et al (2002). "Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation". J. Biol. Chem. 277 (12): 9966–75. doi:10.1074/jbc.M109059200. PMID 11788587. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Mitin NY, Ramocki MB, Zullo AJ et al (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288. 
• Gerhard DS, Wagner L, Feingold EA et al (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Hu H, Bliss JM, Wang Y, Colicelli J (2005). "RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration". Curr. Biol. 15 (9): 815–23. doi:10.1016/j.cub.2005.03.049. PMID 15886098. 
• Zhang Y, Wolf-Yadlin A, Ross PL et al (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell Proteomics 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569. 
• Rual JF, Venkatesan K, Hao T et al (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Hunker CM, Giambini H, Galvis A et al (2006). "Rin1 regulates insulin receptor signal transduction pathways". Exp. Cell Res. 312 (7): 1106–18. doi:10.1016/j.yexcr.2005.12.021. PMID 16457816. 
• Beausoleil SA, Villén J, Gerber SA et al (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. 
• Senda K, Goi T, Hirono Y et al (2007). "Analysis of RIN1 gene expression in colorectal cancer". Oncol. Rep. 17 (5): 1171–5. PMID 17390061. 
• Kong C, Su X, Chen PI, Stahl PD (2007). "Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation". J. Biol. Chem. 282 (20): 15294–301. doi:10.1074/jbc.M611538200. PMID 17403676.