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Receptor-interacting serine-threonine kinase 3
Symbols RIPK3 ; RIP3
External IDs OMIM605817 MGI2154952 HomoloGene31410 IUPHAR: 2191 ChEMBL: 1795199 GeneCards: RIPK3 Gene
EC number
Species Human Mouse
Entrez 11035 56532
Ensembl ENSG00000129465 ENSMUSG00000022221
UniProt Q9Y572 Q9QZL0
RefSeq (mRNA) NM_006871 NM_001164107
RefSeq (protein) NP_006862 NP_001157579
Location (UCSC) Chr 14:
24.81 – 24.81 Mb
Chr 14:
55.78 – 55.79 Mb
PubMed search [1] [2]

Receptor-interacting serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the RIPK3 gene.[1][2][3][4]

The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.[3]


RIPK3 has been shown to interact with RIPK1.[1][4]


  1. ^ a b Yu PW, Huang BC, Shen M, Quast J, Chan E, Xu X, Nolan GP, Payan DG, Luo Y (Jun 1999). "Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB". Curr Biol 9 (10): 539–42. doi:10.1016/S0960-9822(99)80239-5. PMID 10339433. 
  2. ^ Sun X, Lee J, Navas T, Baldwin DT, Stewart TA, Dixit VM (Jul 1999). "RIP3, a novel apoptosis-inducing kinase". J Biol Chem 274 (24): 16871–5. doi:10.1074/jbc.274.24.16871. PMID 10358032. 
  3. ^ a b "Entrez Gene: RIPK3 receptor-interacting serine-threonine kinase 3". 
  4. ^ a b Li J, McQuade T, Siemer AB, Napetschnig J, Moriwaki K, Hsiao YS, Damko E, Moquin D, Walz T, McDermott A, Chan FK, Wu H. (July 2012) The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell 150 (2):339-50.doi: 10.1016/j.cell.2012.06.019. PMID 22817896

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