RNA-binding protein

RNA-binding proteins are proteins that bind to RNA. They bind to either double-strand or single-strand RNAs through RNA recognition motif (RRM). RNA-binding proteins (often abbreviated as RBP) may regulate the translation of RNA, and post-transcriptional events, such as RNA splicing, editing.

They are cytoplasmic and nuclear proteins. However, since most mature RNA is exported from the nucleus relatively quickly, most RBPs in the nucleus exist as complexes of protein and pre-mRNA called heterogeneous ribonucleoprotein particles (hnRNPs).

Examples

Some examples include: translation initiation factors that bind RNA, polyA-binding proteins, snRNPs, ADAR, etc.

External links

• starBase database: a database for decoding binding sites of RNA binding proteins (RBPs) from CLIP-Seq (HITS-CLIP, PAR-CLIP, iCLIP) data.
• RBPDB database: a database of RNA binding proteins.