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Ribonuclease H1
PDB 2qk9 EBI.png
PDB rendering based on 2qk9.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RNASEH1 ; H1RNA; RNH1
External IDs OMIM604123 MGI1335073 HomoloGene2202 ChEMBL: 5893 GeneCards: RNASEH1 Gene
EC number
Species Human Mouse
Entrez 246243 19819
Ensembl ENSG00000171865 ENSMUSG00000020630
UniProt O60930 E9QLN8
RefSeq (mRNA) NM_002936 NM_011275
RefSeq (protein) NP_002927 NP_035405
Location (UCSC) Chr 2:
3.59 – 3.61 Mb
Chr 12:
28.65 – 28.66 Mb
PubMed search [1] [2]

Ribonuclease H1 also known as RNase H1 is an enzyme that in humans is encoded by the RNASEH1 gene.[1][2][3] The RNase H1 is a non-specific endonuclease and catalyzes the cleavage of RNA via a hydrolytic mechanism.


  1. ^ "Entrez Gene: ribonuclease H1". 
  2. ^ ten Asbroek AL, van Groenigen M, Jakobs ME, Koevoets C, Janssen B, Baas F (June 2002). "Ribonuclease H1 maps to chromosome 2 and has at least three pseudogene loci in the human genome". Genomics 79 (6): 818–23. doi:10.1006/geno.2002.6776. PMID 12036296. 
  3. ^ Nowotny M, Gaidamakov SA, Ghirlando R, Cerritelli SM, Crouch RJ, Yang W (October 2007). "Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription". Mol. Cell 28 (2): 264–76. doi:10.1016/j.molcel.2007.08.015. PMID 17964265. 

Further reading[edit]