RNA silencing
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RNA silencing (also called as post-transcriptional gene silencing PTGS) refers to a family of gene silencing effects by which the expression of one or more genes is downregulated or entirely suppressed by the introduction of an antisense RNA molecule. The most common and well-studied example is RNA interference, in which endogenously expressed microRNA or exogenously derived small interfering RNA induces the degradation of complementary messenger RNA. It also plays an important role in defending plants against viruses. Enzymes detect double stranded RNA (that is not normally found in cells) and digest it into small pieces that are not able to cause disease.[1][2][3][4][5]
[edit] See also
[edit] References
- ^ Ding SW (2000). "RNA silencing.". Curr Opin Biotechnol 11 (2): 152–6. PMID 10753772.
- ^ Susi P, Hohkuri M, Wahlroos T, Kilby NJ (2004). "Characteristics of RNA silencing in plants: similarities and differences across kingdoms.". Plant Mol Biol 54 (2): 157–74. PMID 15159620.
- ^ Baulcombe D (2004). "RNA silencing in plants.". Nature 431 (7006): 356–63. doi:10.1038/nature02874. PMID 15372043.
- ^ Baulcombe D (2005). "RNA silencing.". Trends Biochem Sci 30 (6): 290–3. doi:10.1016/j.tibs.2005.04.012. PMID 15950871.
- ^ Meister, G.; Tuschl, T. (2004), "[PDF from blatny.com"], Nature 431 (7006): 343–349, http://www.blatny.com/Epigenetika2007/2007-12-04/papers/Meister%202004.pdf, retrieved 2011-02-08
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