RNF10

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Ring finger protein 10
Identifiers
Symbols RNF10 ; RIE2
External IDs MGI1859162 HomoloGene40990 GeneCards: RNF10 Gene
RNA expression pattern
PBB GE RNF10 207801 s at tn.png
PBB GE RNF10 208632 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9921 50849
Ensembl ENSG00000022840 ENSMUSG00000041740
UniProt Q8N5U6 Q3UIW5
RefSeq (mRNA) NM_014868 NM_016698
RefSeq (protein) NP_055683 NP_057907
Location (UCSC) Chr 12:
120.97 – 121.02 Mb
Chr 5:
115.24 – 115.27 Mb
PubMed search [1] [2]

RING finger protein 10 is a protein that in humans is encoded by the RNF10 gene.[1]

The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known.[1]

Model organisms[edit]

Model organisms have been used in the study of RNF10 function. A conditional knockout mouse line, called Rnf10tm1a(KOMP)Wtsi[10][11] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[12][13][14]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[8][15] Twenty two tests were carried out on mutant mice and five significant abnormalities were observed.[8] Homozygous mutant animals displayed increased chromosomal stability in a micronucleus test. Females also had increased body weight, an increased amount of total body fat and an abnormal complete blood count. Males additionally displayed an increase in eating behavior.[8]

References[edit]

  1. ^ a b "Entrez Gene: RNF10 ring finger protein 10". 
  2. ^ "Body weight data for Rnf10". Wellcome Trust Sanger Institute. 
  3. ^ "Indirect calorimetry data for Rnf10". Wellcome Trust Sanger Institute. 
  4. ^ "DEXA data for Rnf10". Wellcome Trust Sanger Institute. 
  5. ^ "Haematology data for Rnf10". Wellcome Trust Sanger Institute. 
  6. ^ "Salmonella infection data for Rnf10". Wellcome Trust Sanger Institute. 
  7. ^ "Citrobacter infection data for Rnf10". Wellcome Trust Sanger Institute. 
  8. ^ a b c d Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  9. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  10. ^ "International Knockout Mouse Consortium". 
  11. ^ "Mouse Genome Informatics". 
  12. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.  edit
  13. ^ Dolgin E (2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  14. ^ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  15. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353. 

Further reading[edit]