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Ring finger protein 11
Symbols RNF11 ; SID1669
External IDs OMIM612598 MGI1352759 HomoloGene32195 GeneCards: RNF11 Gene
RNA expression pattern
PBB GE RNF11 208924 at tn.png
More reference expression data
Species Human Mouse
Entrez 26994 29864
Ensembl ENSG00000123091 ENSMUSG00000028557
UniProt Q9Y3C5 Q9QYK7
RefSeq (mRNA) NM_014372 NM_013876
RefSeq (protein) NP_055187 NP_038904
Location (UCSC) Chr 1:
51.7 – 51.74 Mb
Chr 4:
109.45 – 109.48 Mb
PubMed search [1] [2]

RING finger protein 11 is a protein that in humans is encoded by the RNF11 gene.[1][2][3]

The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).[3]

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RNF11 has been shown to interact with RIPK1[4] and STAMBP.[5]


  1. ^ Seki N, Hattori A, Hayashi A, Kozuma S, Sasaki M, Suzuki Y, Sugano S, Muramatsu MA, Saito T (March 2000). "Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein". Biochim Biophys Acta 1489 (2–3): 421–7. doi:10.1016/s0167-4781(99)00190-6. PMID 10673045. 
  2. ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (August 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093. 
  3. ^ a b "Entrez Gene: RNF11 ring finger protein 11". 
  4. ^ Shembade, Noula; Parvatiyar Kislay; Harhaj Nicole S; Harhaj Edward W (March 2009). "The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling". EMBO J. (England) 28 (5): 513–22. doi:10.1038/emboj.2008.285. PMC 2657574. PMID 19131965. 
  5. ^ Li, Haoxia; Seth Arun (March 2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene (England) 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. ISSN 0950-9232. PMID 14755250. 

Further reading[edit]

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