RNF11

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Ring finger protein 11
Identifiers
Symbols RNF11 ; SID1669
External IDs OMIM612598 MGI1352759 HomoloGene32195 GeneCards: RNF11 Gene
RNA expression pattern
PBB GE RNF11 208924 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 26994 29864
Ensembl ENSG00000123091 ENSMUSG00000028557
UniProt Q9Y3C5 Q9QYK7
RefSeq (mRNA) NM_014372 NM_013876
RefSeq (protein) NP_055187 NP_038904
Location (UCSC) Chr 1:
51.7 – 51.74 Mb
Chr 4:
109.45 – 109.48 Mb
PubMed search [1] [2]

RING finger protein 11 is a protein that in humans is encoded by the RNF11 gene.[1][2][3]

The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).[3]

See also[edit]

Interactions[edit]

RNF11 has been shown to interact with RIPK1[4] and STAMBP.[5]

References[edit]

  1. ^ Seki N, Hattori A, Hayashi A, Kozuma S, Sasaki M, Suzuki Y, Sugano S, Muramatsu MA, Saito T (March 2000). "Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein". Biochim Biophys Acta 1489 (2–3): 421–7. doi:10.1016/s0167-4781(99)00190-6. PMID 10673045. 
  2. ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (August 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093. 
  3. ^ a b "Entrez Gene: RNF11 ring finger protein 11". 
  4. ^ Shembade, Noula; Parvatiyar Kislay; Harhaj Nicole S; Harhaj Edward W (March 2009). "The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling". EMBO J. (England) 28 (5): 513–22. doi:10.1038/emboj.2008.285. PMC 2657574. PMID 19131965. 
  5. ^ Li, Haoxia; Seth Arun (March 2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene (England) 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. ISSN 0950-9232. PMID 14755250. 

Further reading[edit]

External links[edit]