The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).
^Seki N, Hattori A, Hayashi A, Kozuma S, Sasaki M, Suzuki Y, Sugano S, Muramatsu MA, Saito T (March 2000). "Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein". Biochim Biophys Acta1489 (2–3): 421–7. doi:10.1016/s0167-4781(99)00190-6. PMID10673045.
Kitching R, Wong MJ, Koehler D, et al. (2003). "The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases". Biochim. Biophys. Acta1639 (2): 104–12. doi:10.1016/j.bbadis.2003.07.001. PMID14559117.
Anderson LR, Betarbet R, Gearing M, et al. (2007). "PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain". J. Neuropathol. Exp. Neurol.66 (10): 955–64. doi:10.1097/nen.0b013e3181567f17. PMID17917589.