RNF12

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Ring finger protein, LIM domain interacting
Identifiers
Symbols RLIM ; NY-REN-43; RNF12
External IDs OMIM300379 MGI1342291 HomoloGene7920 GeneCards: RLIM Gene
Orthologs
Species Human Mouse
Entrez 51132 19820
Ensembl ENSG00000131263 ENSMUSG00000056537
UniProt Q9NVW2 Q9WTV7
RefSeq (mRNA) NM_016120 NM_011276
RefSeq (protein) NP_057204 NP_035406
Location (UCSC) Chr X:
73.81 – 73.83 Mb
Chr X:
103.96 – 103.98 Mb
PubMed search [1] [2]

E3 ubiquitin-protein ligase RLIM is an enzyme that in humans is encoded by the RLIM gene.[1][2]

Function[edit]

The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be a ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Alternatively spliced transcript variants encoding the same protein have been reported.[2]

Interactions[edit]

RNF12 has been shown to interact with Estrogen receptor alpha.[3]

References[edit]

  1. ^ Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V et al. (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479. 
  2. ^ a b "Entrez Gene: RNF12 ring finger protein 12". 
  3. ^ Johnsen SA, Güngör C, Prenzel T, Riethdorf S, Riethdorf L, Taniguchi-Ishigaki N et al. (Jan 2009). "Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer". Cancer Res. 69 (1): 128–36. doi:10.1158/0008-5472.CAN-08-1630. PMC 2713826. PMID 19117995. 

Further reading[edit]

  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Hiratani I, Yamamoto N, Mochizuki T, Ohmori SY, Taira M (2003). "Selective degradation of excess Ldb1 by Rnf12/RLIM confers proper Ldb1 expression levels and Xlim-1/Ldb1 stoichiometry in Xenopus organizer functions". Development 130 (17): 4161–75. doi:10.1242/dev.00621. PMID 12874135. 
  • Ostendorff HP, Peirano RI, Peters MA, Schlüter A, Bossenz M, Scheffner M et al. (2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors". Nature 416 (6876): 99–103. doi:10.1038/416099a. PMID 11882901. 
  • Ostendorff HP, Bossenz M, Mincheva A, Copeland NG, Gilbert DJ, Jenkins NA et al. (2000). "Functional characterization of the gene encoding RLIM, the corepressor of LIM homeodomain factors". Genomics 69 (1): 120–30. doi:10.1006/geno.2000.6311. PMID 11013082. 
  • Bach I, Rodriguez-Esteban C, Carrière C, Bhushan A, Krones A, Rose DW et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–9. doi:10.1038/11970. PMID 10431247.