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Ring finger protein 128, E3 ubiquitin protein ligase
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RNF128 ; GRAIL
External IDs OMIM300439 MGI1914139 HomoloGene11337 GeneCards: RNF128 Gene
EC number 6.3.2.-
RNA expression pattern
PBB GE RNF128 219263 at tn.png
More reference expression data
Species Human Mouse
Entrez 79589 66889
Ensembl ENSG00000133135 ENSMUSG00000031438
UniProt Q8TEB7 Q9D304
RefSeq (mRNA) NM_024539 NM_001254761
RefSeq (protein) NP_078815 NP_001241690
Location (UCSC) Chr X:
105.94 – 106.04 Mb
Chr X:
139.56 – 139.67 Mb
PubMed search [1] [2]

E3 ubiquitin-protein ligase RNF128 is an enzyme that in humans is encoded by the RNF128 gene.[1]

The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[1]


RNF128 has been shown to interact with CD154[2] and OTUB1.[3]


  1. ^ a b "Entrez Gene: RNF128 ring finger protein 128". 
  2. ^ Lineberry, Neil B; Su Leon L; Lin Jack T; Coffey Greg P; Seroogy Christine M; Fathman C Garrison (Aug 2008). "Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy". J. Immunol. (United States) 181 (3): 1622–6. doi:10.4049/jimmunol.181.3.1622. PMC 2853377. PMID 18641297. 
  3. ^ Soares, Luis; Seroogy Christine; Skrenta Heidi; Anandasabapathy Niroshana; Lovelace Patricia; Chung Chan D; Engleman Edgar; Fathman C Garrison (Jan 2004). "Two isoforms of otubain 1 regulate T cell anergy via GRAIL". Nat. Immunol. (United States) 5 (1): 45–54. doi:10.1038/ni1017. ISSN 1529-2908. PMID 14661020. 

Further reading[edit]