RNF139

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Ring finger protein 139
Identifiers
Symbols RNF139 ; HRCA1; RCA1; TRC8
External IDs OMIM603046 MGI1923091 HomoloGene5222 GeneCards: RNF139 Gene
RNA expression pattern
PBB GE RNF139 209510 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11236 75841
Ensembl ENSG00000170881 ENSMUSG00000037075
UniProt Q8WU17 Q7TMV1
RefSeq (mRNA) NM_007218 NM_175226
RefSeq (protein) NP_009149 NP_780435
Location (UCSC) Chr 8:
125.49 – 125.5 Mb
Chr 15:
58.89 – 58.9 Mb
PubMed search [1] [2]

RING finger protein 139 is a protein that in humans is encoded by the RNF139 gene.[1][2]

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.[2]

References[edit]

  1. ^ Gemmill RM, West JD, Boldog F, Tanaka N, Robinson LJ, Smith DI, Li F, Drabkin HA (Sep 1998). "The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8". Proc Natl Acad Sci U S A 95 (16): 9572–7. doi:10.1073/pnas.95.16.9572. PMC 21380. PMID 9689122. 
  2. ^ a b "Entrez Gene: RNF139 ring finger protein 139". 

Further reading[edit]