RING finger protein 139 is a protein that in humans is encoded by the RNF139gene.
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.
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Gemmill RM, Bemis LT, Lee JP et al. (2002). "The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway.". Oncogene21 (22): 3507–16. doi:10.1038/sj.onc.1205437. PMID12032852.CS1 maint: Explicit use of et al. (link)