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Ring finger protein 139
Symbols RNF139 ; HRCA1; RCA1; TRC8
External IDs OMIM603046 MGI1923091 HomoloGene5222 GeneCards: RNF139 Gene
RNA expression pattern
PBB GE RNF139 209510 at tn.png
More reference expression data
Species Human Mouse
Entrez 11236 75841
Ensembl ENSG00000170881 ENSMUSG00000037075
UniProt Q8WU17 Q7TMV1
RefSeq (mRNA) NM_007218 NM_175226
RefSeq (protein) NP_009149 NP_780435
Location (UCSC) Chr 8:
125.49 – 125.5 Mb
Chr 15:
58.89 – 58.9 Mb
PubMed search [1] [2]

RING finger protein 139 is a protein that in humans is encoded by the RNF139 gene.[1][2]

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.[2]


  1. ^ Gemmill RM, West JD, Boldog F, Tanaka N, Robinson LJ, Smith DI, Li F, Drabkin HA (Sep 1998). "The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8". Proc Natl Acad Sci U S A 95 (16): 9572–7. doi:10.1073/pnas.95.16.9572. PMC 21380. PMID 9689122. 
  2. ^ a b "Entrez Gene: RNF139 ring finger protein 139". 

Further reading[edit]