RNF20

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Ring finger protein 20, E3 ubiquitin protein ligase
Identifiers
Symbols RNF20 ; BRE1; BRE1A; hBRE1
External IDs OMIM607699 MGI1925927 HomoloGene5571 GeneCards: RNF20 Gene
RNA expression pattern
PBB GE RNF20 gnf1h00327 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 56254 109331
Ensembl ENSG00000155827 ENSMUSG00000028309
UniProt Q5VTR2 Q5DTM8
RefSeq (mRNA) NM_019592 NM_001163263
RefSeq (protein) NP_062538 NP_001156735
Location (UCSC) Chr 9:
104.3 – 104.33 Mb
Chr 4:
49.63 – 49.66 Mb
PubMed search [1] [2]

E3 ubiquitin-protein ligase BRE1A is an enzyme that in humans is encoded by the RNF20 gene.[1][2][3][4][5]

The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. Yeast BRE1 is a ubiquitin ligase required for the ubiquitination of histone H2B and the methylation of histone H3.[5]

See also[edit]

References[edit]

  1. ^ Kim J, Hake SB, Roeder RG (Dec 2005). "The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions". Mol Cell 20 (5): 759–70. doi:10.1016/j.molcel.2005.11.012. PMID 16337599. 
  2. ^ Wood A, Schneider J, Dover J, Johnston M, Shilatifard A (Sep 2003). "The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p". J Biol Chem 278 (37): 34739–42. doi:10.1074/jbc.C300269200. PMID 12876294. 
  3. ^ Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M (Oct 2008). "The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression". Genes Dev 22 (19): 2664–76. doi:10.1101/gad.1703008. PMC 2559905. PMID 18832071. 
  4. ^ Liu Z, Oh SM, Okada M, Liu X, Cheng D, Peng J, Brat DJ, Sun SY, Zhou W, Gu W, Ye K (Feb 2009). "Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor". Mol Biol Cell 20 (3): 757–68. doi:10.1091/mbc.E08-09-0983. PMC 2633391. PMID 19037095. 
  5. ^ a b "Entrez Gene: RNF20 ring finger protein 20". 

Further reading[edit]

External links[edit]