From Wikipedia, the free encyclopedia
Jump to: navigation, search
Ring finger protein 20, E3 ubiquitin protein ligase
Symbols RNF20 ; BRE1; BRE1A; hBRE1
External IDs OMIM607699 MGI1925927 HomoloGene5571 GeneCards: RNF20 Gene
RNA expression pattern
PBB GE RNF20 gnf1h00327 at tn.png
More reference expression data
Species Human Mouse
Entrez 56254 109331
Ensembl ENSG00000155827 ENSMUSG00000028309
UniProt Q5VTR2 Q5DTM8
RefSeq (mRNA) NM_019592 NM_001163263
RefSeq (protein) NP_062538 NP_001156735
Location (UCSC) Chr 9:
104.3 – 104.33 Mb
Chr 4:
49.63 – 49.66 Mb
PubMed search [1] [2]

E3 ubiquitin-protein ligase BRE1A is an enzyme that in humans is encoded by the RNF20 gene.[1][2][3][4][5]

The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. Yeast BRE1 is a ubiquitin ligase required for the ubiquitination of histone H2B and the methylation of histone H3.[5]

See also[edit]


  1. ^ Kim J, Hake SB, Roeder RG (Dec 2005). "The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions". Mol Cell 20 (5): 759–70. doi:10.1016/j.molcel.2005.11.012. PMID 16337599. 
  2. ^ Wood A, Schneider J, Dover J, Johnston M, Shilatifard A (Sep 2003). "The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p". J Biol Chem 278 (37): 34739–42. doi:10.1074/jbc.C300269200. PMID 12876294. 
  3. ^ Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M (Oct 2008). "The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression". Genes Dev 22 (19): 2664–76. doi:10.1101/gad.1703008. PMC 2559905. PMID 18832071. 
  4. ^ Liu Z, Oh SM, Okada M, Liu X, Cheng D, Peng J, Brat DJ, Sun SY, Zhou W, Gu W, Ye K (Feb 2009). "Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor". Mol Biol Cell 20 (3): 757–68. doi:10.1091/mbc.E08-09-0983. PMC 2633391. PMID 19037095. 
  5. ^ a b "Entrez Gene: RNF20 ring finger protein 20". 

Further reading[edit]

External links[edit]