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Ring finger protein 4
Protein RNF4 PDB 2EA6.png
Rendering based on PDB 2EA6.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RNF4 ; SLX5; SNURF
External IDs OMIM602850 MGI1201691 HomoloGene37711 GeneCards: RNF4 Gene
Species Human Mouse
Entrez 6047 19822
Ensembl ENSG00000063978 ENSMUSG00000029110
UniProt P78317 Q9QZS2
RefSeq (mRNA) NM_001185009 NM_011278
RefSeq (protein) NP_001171938 NP_035408
Location (UCSC) Chr 4:
2.46 – 2.63 Mb
Chr 5:
34.34 – 34.36 Mb
PubMed search [1] [2]

RING finger protein 4 is a protein that in humans is encoded by the RNF4 gene.[1][2]

The protein encoded by this gene contains a RING finger domain and acts as a transcription factor. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ1 is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis.[2]


RNF4 has been shown to interact with TCF20,[3] PATZ1[4][5] and Androgen receptor.[5][6][7]

See also[edit]


  1. ^ Chiariotti L, Benvenuto G, Fedele M, Santoro M, Simeone A, Fusco A, Bruni CB (April 1998). "Identification and characterization of a novel RING-finger gene (RNF4) mapping at 4p16.3". Genomics 47 (2): 258–65. doi:10.1006/geno.1997.5105. PMID 9479498. 
  2. ^ a b "Entrez Gene: RNF4 ring finger protein 4". 
  3. ^ Lyngsø, C; Bouteiller G; Damgaard C K; Ryom D; Sanchez-Muñoz S; Nørby P L; Bonven B J; Jørgensen P (August 2000). "Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers". J. Biol. Chem. (United States) 275 (34): 26144–9. doi:10.1074/jbc.M003405200. ISSN 0021-9258. PMID 10849425. 
  4. ^ Fedele, M; Benvenuto G, Pero R, Majello B, Battista S, Lembo F, Vollono E, Day P M, Santoro M, Lania L, Bruni C B, Fusco A, Chiariotti L (March 2000). "A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor". J. Biol. Chem. (United States) 275 (11): 7894–901. doi:10.1074/jbc.275.11.7894. ISSN 0021-9258. PMID 10713105. 
  5. ^ a b Pero, Raffaela; Lembo Francesca; Palmieri Emiliano Antonio; Vitiello Carmen; Fedele Monica; Fusco Alfredo; Bruni Carmelo Bruno; Chiariotti Lorenzo (February 2002). "PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription". J. Biol. Chem. (United States) 277 (5): 3280–5. doi:10.1074/jbc.M109491200. ISSN 0021-9258. PMID 11719514. 
  6. ^ Moilanen, A M; Poukka H; Karvonen U; Häkli M; Jänne O A; Palvimo J J (September 1998). "Identification of a Novel RING Finger Protein as a Coregulator in Steroid Receptor-Mediated Gene Transcription". Mol. Cell. Biol. (United States) 18 (9): 5128–39. ISSN 0270-7306. PMC 109098. PMID 9710597. 
  7. ^ Poukka, H; Aarnisalo P; Santti H; Jänne O A; Palvimo J J (January 2000). "Coregulator small nuclear RING finger protein (SNURF) enhances Sp1- and steroid receptor-mediated transcription by different mechanisms". J. Biol. Chem. (United States) 275 (1): 571–9. doi:10.1074/jbc.275.1.571. ISSN 0021-9258. PMID 10617653. 

Further reading[edit]

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