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Ring finger protein 41, E3 ubiquitin protein ligase
Protein RNF41 PDB 2fzp.png
PDB rendering based on 2fzp.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RNF41 ; FLRF; NRDP1
External IDs MGI1914838 HomoloGene4226 GeneCards: RNF41 Gene
EC number 6.3.2.-
RNA expression pattern
PBB GE RNF41 201961 s at tn.png
PBB GE RNF41 201962 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10193 67588
Ensembl ENSG00000181852 ENSMUSG00000025373
UniProt Q9H4P4 Q8BH75
RefSeq (mRNA) NM_001242826 NM_001164237
RefSeq (protein) NP_001229755 NP_001157709
Location (UCSC) Chr 12:
56.6 – 56.62 Mb
Chr 10:
128.41 – 128.44 Mb
PubMed search [1] [2]

E3 ubiquitin-protein ligase NRDP1 is an enzyme that in humans is encoded by the RNF41 gene.[1]


The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The specific function of this protein has not yet been determined. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.[1]


RNF41 has been shown to interact with USP8.[2]

See also[edit]


  1. ^ a b "Entrez Gene: RNF41 ring finger protein 41". 
  2. ^ Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (September 2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180. 

Further reading[edit]

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