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Ring finger protein 8, E3 ubiquitin protein ligase
Protein RNF8 PDB 2csw.png
PDB rendering based on 2csw.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RNF8 ; hRNF8
External IDs OMIM611685 MGI1929069 HomoloGene2944 GeneCards: RNF8 Gene
EC number 6.3.2.-
RNA expression pattern
PBB GE RNF8 203160 s at tn.png
PBB GE RNF8 203161 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9025 58230
Ensembl ENSG00000112130 ENSMUSG00000090083
UniProt O76064 Q8VC56
RefSeq (mRNA) NM_003958 NM_021419
RefSeq (protein) NP_003949 NP_067394
Location (UCSC) Chr 6:
37.32 – 37.36 Mb
Chr 17:
29.61 – 29.64 Mb
PubMed search [1] [2]

E3 ubiquitin-protein ligase RNF8 is an enzyme that in humans is encoded by the RNF8 gene.[1][2][3]

The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as a ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]


RNF8 has been shown to interact with Retinoid X receptor alpha.[4]

See also[edit]


  1. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811. 
  2. ^ Seki N, Hattori A, Sugano S, Suzuki Y, Nakagawara A, Ohhira M, Muramatsu M, Hori T, Saito T (Jan 1999). "Isolation, tissue expression, and chromosomal assignment of a novel human gene which encodes a protein with RING finger motif". J Hum Genet 43 (4): 272–4. doi:10.1007/s100380050088. PMID 9852682. 
  3. ^ a b "Entrez Gene: RNF8 ring finger protein 8". 
  4. ^ Takano, Yukihiko; Adachi Seiji, Okuno Masataka, Muto Yoshinori, Yoshioka Takashi, Matsushima-Nishiwaki Rie, Tsurumi Hisashi, Ito Kenichi, Friedman Scott L, Moriwaki Hisataka, Kojima Soichi, Okano Yukio (Apr 2004). "The RING finger protein, RNF8, interacts with retinoid X receptor alpha and enhances its transcription-stimulating activity". J. Biol. Chem. (United States) 279 (18): 18926–34. doi:10.1074/jbc.M309148200. ISSN 0021-9258. PMID 14981089. 

Further reading[edit]

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