Rho-associated, coiled-coil-containing protein kinase 1, also known as ROCK1, is a protein serine/threonine kinase, but also denotes the human gene encoding it.
It is activated when bound to the GTP-bound form of Rho GTPase. Thus, this protein is a downstream effector of Rho. It phosphorylates and activates LIM kinase, which, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. Thus, ROCK1 contributes to actin-stability.
^Fujisawa, K; Fujita A, Ishizaki T, Saito Y, Narumiya S (Sep 1996). "Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase". J. Biol. Chem. (UNITED STATES) 271 (38): 23022–8. doi:10.1074/jbc.271.38.23022. ISSN0021-9258. PMID8798490.Cite uses deprecated parameters (help)