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ROS proto-oncogene 1 , receptor tyrosine kinase
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ROS1 ; MCF3; ROS; c-ros-1
External IDs OMIM165020 MGI97999 HomoloGene2207 IUPHAR: 1840 ChEMBL: 5568 GeneCards: ROS1 Gene
EC number
RNA expression pattern
PBB GE ROS1 207569 at tn.png
More reference expression data
Species Human Mouse
Entrez 6098 19886
Ensembl ENSG00000047936 ENSMUSG00000019893
UniProt P08922 Q78DX7
RefSeq (mRNA) NM_002944 NM_011282
RefSeq (protein) NP_002935 NP_035412
Location (UCSC) Chr 6:
117.61 – 117.75 Mb
Chr 10:
52.05 – 52.2 Mb
PubMed search [1] [2]

Proto-oncogene tyrosine-protein kinase ROS is an enzyme that in humans is encoded by the ROS1 gene.[1][2]


This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.[2]


ROS1 (gene) has been shown to interact with PTPN6.[3]


  1. ^ Galland F, Stefanova M, Lafage M, Birnbaum D (July 1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23". Cytogenetics and Cell Genetics 60 (2): 114–6. doi:10.1159/000133316. PMID 1611909. 
  2. ^ a b "Entrez Gene: ROS1 v-ros UR2 sarcoma virus oncogene homolog 1 (avian)". 
  3. ^ Keilhack H, Müller M, Böhmer SA, Frank C, Weidner KM, Birchmeier W et al. (Jan 2001). "Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1". The Journal of Cell Biology 152 (2): 325–34. doi:10.1083/jcb.152.2.325. PMC 2199605. PMID 11266449. 

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