The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Lin JL, Chen HC, Fang HI, Robinson D, Kung HJ, Shih HM (2001). "MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway". Oncogene20 (45): 6559–69. doi:10.1038/sj.onc.1204818. PMID11641781.
Dan I, Ong SE, Watanabe NM, Blagoev B, Nielsen MM, Kajikawa E et al. (2002). "Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties". J. Biol. Chem.277 (8): 5929–39. doi:10.1074/jbc.M110882200. PMID11741893.
Sung V, Luo W, Qian D, Lee I, Jallal B, Gishizky M (2003). "The Ste20 kinase MST4 plays a role in prostate cancer progression". Cancer Res.63 (12): 3356–63. PMID12810671.
Chan EH, Nousiainen M, Chalamalasetty RB, Schäfer A, Nigg EA, Silljé HH (2005). "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1". Oncogene24 (12): 2076–86. doi:10.1038/sj.onc.1208445. PMID15688006.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.