MST4

From Wikipedia, the free encyclopedia
  (Redirected from RP6-213H19.1)
Jump to: navigation, search
Serine/threonine protein kinase MST4
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MST4 ; MASK
External IDs OMIM300547 MGI1917665 HomoloGene84402 ChEMBL: 5941 GeneCards: MST4 Gene
EC number 2.7.11.1
RNA expression pattern
PBB GE RP6-213H19.1 218499 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51765 70415
Ensembl ENSG00000134602 ENSMUSG00000031112
UniProt Q9P289 Q99JT2
RefSeq (mRNA) NM_001042452 NM_133729
RefSeq (protein) NP_001035917 NP_598490
Location (UCSC) Chr X:
131.16 – 131.21 Mb
Chr X:
50.84 – 50.89 Mb
PubMed search [1] [2]

Serine/threonine protein kinase MST4, also known as mammalian STE20-like protein kinase 4 (MST-4), is a protein that in humans is encoded by the MST4 gene.[1]

Function[edit]

The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[1]

Interactions[edit]

RP6-213H19.1 has been shown to interact with STRN,[2] PDCD10,[2] CTTNBP2,[2] STRN3,[2] MOBKL3,[2] CTTNBP2NL[2] and FAM40A.[2]

References[edit]

  1. ^ a b "Entrez Gene: RP6-213H19.1 serine/threonine protein kinase MST4". 
  2. ^ a b c d e f g Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (January 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell Proteomics 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753. 

Further reading[edit]