RPL10A

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Ribosomal protein L10a
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RPL10A ; CSA19; Csa-19; L10A; NEDD6
External IDs OMIM615660 MGI1343877 HomoloGene68543 GeneCards: RPL10A Gene
EC number 3.6.5.3
Orthologs
Species Human Mouse
Entrez 4736 19896
Ensembl ENSG00000198755 ENSMUSG00000037805
UniProt P62906 P53026
RefSeq (mRNA) NM_007104 NM_011287
RefSeq (protein) NP_009035 NP_035417
Location (UCSC) Chr 6:
35.44 – 35.44 Mb
Chr 17:
28.33 – 28.33 Mb
PubMed search [1] [2]

60S ribosomal protein L10a is a protein that in humans is encoded by the RPL10A gene.[1][2][3]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3]

References[edit]

  1. ^ Fisicaro N, Katerelos M, Williams J, Power D, D'Apice A, Pearse M (Aug 1995). "Identification of genes downregulated in the thymus by cyclosporin-A: preliminary characterization of clone CSA-19". Mol Immunol 32 (8): 565–72. doi:10.1016/0161-5890(95)00032-A. PMID 7609734. 
  2. ^ Tripodis N, Mason R, Humphray SJ, Davies AF, Herberg JA, Trowsdale J, Nizetic D, Senger G, Ragoussis J (Jan 1999). "Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex". Genome Res 8 (6): 631–43. doi:10.1101/gr.8.6.631. PMC 310739. PMID 9647638. 
  3. ^ a b "Entrez Gene: RPL10A ribosomal protein L10a". 

Further reading[edit]