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Ribosomal protein L12
Protein RPL12 PDB 1wib.png
PDB rendering based on 1wib.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RPL12 ; L12
External IDs OMIM180475 MGI98002 HomoloGene128047 GeneCards: RPL12 Gene
RNA expression pattern
PBB GE RPL12 200809 x at tn.png
PBB GE RPL12 214271 x at tn.png
More reference expression data
Species Human Mouse
Entrez 6136 269261
Ensembl ENSG00000197958 ENSMUSG00000038900
UniProt P30050 P35979
RefSeq (mRNA) NM_000976 NM_009076
RefSeq (protein) NP_000967 NP_033102
Location (UCSC) Chr 9:
130.21 – 130.21 Mb
Chr 10:
29.7 – 29.7 Mb
PubMed search [1] [2]

60S ribosomal protein L12' is a protein that in humans is encoded by the RPL12 gene.[1][2]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L11P family of ribosomal proteins. It is located in the cytoplasm. The protein binds directly to the 26S rRNA. This gene is co-transcribed with the U65 snoRNA, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[2]


RPL12 has been shown to interact with CDC5L.[3]


  1. ^ Chu W, Presky DH, Swerlick RA, Burns DK (March 1993). "The primary structure of human ribosomal protein L12". Nucleic Acids Res 21 (3): 749. doi:10.1093/nar/21.3.749. PMC 309184. PMID 8441690. 
  2. ^ a b "Entrez Gene: RPL12 ribosomal protein L12". 
  3. ^ Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. (ENGLAND) 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529. 

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