RPL13

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Ribosomal protein L13
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RPL13 ; BBC1; D16S444E; D16S44E; L13
External IDs OMIM113703 MGI105922 HomoloGene5568 GeneCards: RPL13 Gene
EC number 3.6.5.3
RNA expression pattern
PBB GE RPL13 212191 x at tn.png
PBB GE RPL13 208929 x at tn.png
PBB GE RPL13 212734 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6137 270106
Ensembl ENSG00000167526 ENSMUSG00000000740
UniProt P26373 P47963
RefSeq (mRNA) NM_000977 NM_016738
RefSeq (protein) NP_000968 NP_058018
Location (UCSC) Chr 16:
89.63 – 89.63 Mb
Chr 8:
123.1 – 123.11 Mb
PubMed search [1] [2]

60S ribosomal protein L13' is a protein that in humans is encoded by the RPL13 gene.[1][2]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13E family of ribosomal proteins. It is located in the cytoplasm. This gene is expressed at significantly higher levels in benign breast lesions than in breast carcinomas. Transcript variants derived from alternative splicing and/or alternative polyadenylation exist; these variants encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[2]

Interactions[edit]

RPL13 has been shown to interact with CDC5L.[3]

References[edit]

  1. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (August 1998). "A map of 75 human ribosomal protein genes". Genome Res 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194. 
  2. ^ a b "Entrez Gene: RPL13 ribosomal protein L13". 
  3. ^ Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. (ENGLAND) 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529. 

Further reading[edit]