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For the programming language RPL-3, see Filetab.
Ribosomal protein L3
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RPL3 ; ASC-1; L3; TARBP-B
External IDs OMIM604163 MGI1351605 HomoloGene747 GeneCards: RPL3 Gene
Species Human Mouse
Entrez 6122 27367
Ensembl ENSG00000100316 ENSMUSG00000060036
UniProt P39023 P27659
RefSeq (mRNA) NM_000967 NM_013762
RefSeq (protein) NP_000958 NP_038790
Location (UCSC) Chr 22:
39.71 – 39.72 Mb
Chr 15:
80.08 – 80.08 Mb
PubMed search [1] [2]

60S ribosomal protein L3 is a protein that in humans is encoded by the RPL3 gene.[1][2][3]


Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3]


  1. ^ Ou JH, Yen TS, Wang YF, Kam WK, Rutter WJ (Jan 1988). "Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells". Nucleic Acids Res 15 (21): 8919–34. doi:10.1093/nar/15.21.8919. PMC 306413. PMID 2891103. 
  2. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ et al. (May 1998). "A Map of 75 Human Ribosomal Protein Genes". Genome Research 8 (5): 509–523. doi:10.1101/gr.8.5.509 (inactive 2015-01-09). PMID 9582194. 
  3. ^ a b "Entrez Gene: RPL3 ribosomal protein L3". 

Further reading[edit]

  • Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009. 
  • Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR et al. (1992). "Sequence identification of 2,375 human brain genes". Nature 355 (6361): 632–4. doi:10.1038/355632a0. PMID 1538749. 
  • Reddy TR, Suhasini M, Rappaport J, Looney DJ, Kraus G, Wong-Staal F (1995). "Molecular cloning and characterization of a TAR-binding nuclear factor from T cells". AIDS Res. Hum. Retroviruses 11 (6): 663–9. doi:10.1089/aid.1995.11.663. PMID 7576925. 
  • Matoba R, Okubo K, Hori N, Fukushima A, Matsubara K (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819. 
  • Van Raay TJ, Connors TD, Klinger KW, Landes GM, Burn TC (1997). "A novel ribosomal protein L3-like gene (RPL3L) maps to the autosomal dominant polycystic kidney disease gene region". Genomics 37 (2): 172–6. doi:10.1006/geno.1996.0538. PMID 8921388. 
  • Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  • Duga S, Asselta R, Malcovati M, Tenchini ML, Ronchi S, Simonic T (2000). "The intron-containing L3 ribosomal protein gene (RPL3): sequence analysis and identification of U43 and of two novel intronic small nucleolar RNAs". Biochim. Biophys. Acta 1490 (3): 225–36. doi:10.1016/S0167-4781(99)00237-7. PMID 10684968. 
  • Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437. 
  • Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. 
  • Odintsova TI, Müller EC, Ivanov AV, Egorov TA, Bienert R, Vladimirov SN et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–58. doi:10.1023/A:1025068419698. PMID 12962325. 
  • Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. 
  • Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802. 
  • Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. 
  • Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.