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For the programming language RPL-3, see Filetab.
Ribosomal protein L3
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RPL3 ; ASC-1; L3; TARBP-B
External IDs OMIM604163 MGI1351605 HomoloGene747 GeneCards: RPL3 Gene
Species Human Mouse
Entrez 6122 27367
Ensembl ENSG00000100316 ENSMUSG00000060036
UniProt P39023 P27659
RefSeq (mRNA) NM_000967 NM_013762
RefSeq (protein) NP_000958 NP_038790
Location (UCSC) Chr 22:
39.71 – 39.72 Mb
Chr 15:
80.08 – 80.08 Mb
PubMed search [1] [2]

60S ribosomal protein L3 is a protein that in humans is encoded by the RPL3 gene.[1][2][3]


Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3]


  1. ^ Ou JH, Yen TS, Wang YF, Kam WK, Rutter WJ (Jan 1988). "Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells". Nucleic Acids Res 15 (21): 8919–34. doi:10.1093/nar/15.21.8919. PMC 306413. PMID 2891103. 
  2. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (May 1998). "A Map of 75 Human Ribosomal Protein Genes". Genome Research 8 (5): 509–523. doi:10.1101/gr.8.5.509 (inactive 2012-08-07). PMID 9582194.  edit
  3. ^ a b "Entrez Gene: RPL3 ribosomal protein L3". 

Further reading[edit]