RPL7A

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Ribosomal protein L7a
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RPL7A ; L7A; SURF3; TRUP
External IDs OMIM185640 MGI3649050 HomoloGene105462 GeneCards: RPL7A Gene
Orthologs
Species Human Mouse
Entrez 6130 27176
Ensembl ENSG00000148303 ENSMUSG00000062647
UniProt P62424 P12970
RefSeq (mRNA) NM_000972 NM_013721
RefSeq (protein) NP_000963 NP_038749
Location (UCSC) Chr 9:
136.22 – 136.22 Mb
Chr 2:
26.91 – 26.91 Mb
PubMed search [1] [2]

60S ribosomal protein L7a is a protein that in humans is encoded by the RPL7A gene.[1][2][3]

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3]

References[edit]

  1. ^ Ziemiecki A, Muller RG, Fu XC, Hynes NE, Kozma S (Feb 1990). "Oncogenic activation of the human trk proto-oncogene by recombination with the ribosomal large subunit protein L7a". EMBO J 9 (1): 191–6. PMC 551645. PMID 2403926. 
  2. ^ Kozma SC, Redmond SM, Fu XC, Saurer SM, Groner B, Hynes NE (May 1988). "Activation of the receptor kinase domain of the trk oncogene by recombination with two different cellular sequences". EMBO J 7 (1): 147–54. PMC 454232. PMID 2966065. 
  3. ^ a b "Entrez Gene: RPL7A ribosomal protein L7a". 

Further reading[edit]