RPL8

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Ribosomal protein L8
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RPL8 ; L8
External IDs OMIM604177 MGI1350927 HomoloGene32141 GeneCards: RPL8 Gene
RNA expression pattern
PBB GE RPL8 200936 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6132 26961
Ensembl ENSG00000161016 ENSMUSG00000003970
UniProt P62917 P62918
RefSeq (mRNA) NM_000973 NM_012053
RefSeq (protein) NP_000964 NP_036183
Location (UCSC) Chr 8:
146.02 – 146.02 Mb
Chr 15:
76.9 – 76.91 Mb
PubMed search [1] [2]

60S ribosomal protein L8 is a protein that in humans is encoded by the RPL8 gene.[1][2][3]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3]

References[edit]

  1. ^ Hanes J, Klaudiny J, von der Kammer H, Scheit KH (Feb 1994). "Characterization by cDNA cloning of the mRNA of human ribosomal protein L8". Biochem Biophys Res Commun 197 (3): 1223–8. doi:10.1006/bbrc.1993.2607. PMID 7506540. 
  2. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194. 
  3. ^ a b "Entrez Gene: RPL8 ribosomal protein L8". 

Further reading[edit]