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Ribosomal protein S12
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RPS12 ; S12
External IDs OMIM603660 MGI98105 HomoloGene110750 GeneCards: RPS12 Gene
RNA expression pattern
PBB GE RPS12 213377 x at tn.png
More reference expression data
Species Human Mouse
Entrez 6206 20042
Ensembl ENSG00000112306 ENSMUSG00000061983
UniProt P25398 Q6ZWZ6
RefSeq (mRNA) NM_001016 NM_011295
RefSeq (protein) NP_001007 NP_035425
Location (UCSC) Chr 6:
133.14 – 133.14 Mb
Chr 10:
23.79 – 23.79 Mb
PubMed search [1] [2]

40S ribosomal protein S12 is a protein that in humans is encoded by the RPS12 gene.[1][2][3]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3]


  1. ^ Herault Y, Michel D, Chatelain G, Brun G (Aug 1991). "cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17". Nucleic Acids Res 19 (14): 4001. doi:10.1093/nar/19.14.4001. PMC 328500. PMID 1861993. 
  2. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194. 
  3. ^ a b "Entrez Gene: RPS12 ribosomal protein S12". 

Further reading[edit]