RPS13

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Ribosomal protein S13
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RPS13 ; S13
External IDs OMIM180476 MGI1915302 HomoloGene128182 GeneCards: RPS13 Gene
EC number 3.6.5.3
Orthologs
Species Human Mouse
Entrez 6207 68052
Ensembl ENSG00000110700 ENSMUSG00000090862
UniProt P62277 P62301
RefSeq (mRNA) NM_001017 NM_026533
RefSeq (protein) NP_001008 NP_080809
Location (UCSC) Chr 11:
17.1 – 17.1 Mb
Chr 7:
116.33 – 116.33 Mb
PubMed search [1] [2]

40S ribosomal protein S13 is a protein that in humans is encoded by the RPS13 gene.[1][2][3]

Function[edit]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3]

Interactions[edit]

RPS13 has been shown to interact with PDCD4.[4]

References[edit]

  1. ^ Chadeneau C, LeMoullac B, Denis MG (Aug 1993). "Cloning and analysis of the human S13 ribosomal protein cDNA". Nucleic Acids Res 21 (12): 2945. doi:10.1093/nar/21.12.2945. PMC 309694. PMID 8332508. 
  2. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194. 
  3. ^ a b "Entrez Gene: RPS13 ribosomal protein S13". 
  4. ^ Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY (April 2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochem. Biophys. Res. Commun. 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647. 

Further reading[edit]