RPS14

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Ribosomal protein S14
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RPS14 ; EMTB; S14
External IDs OMIM130620 MGI98107 HomoloGene90926 GeneCards: RPS14 Gene
RNA expression pattern
PBB GE RPS14 208645 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6208 20044
Ensembl ENSG00000164587 ENSMUSG00000024608
UniProt P62263 P62264
RefSeq (mRNA) NM_001025070 NM_020600
RefSeq (protein) NP_001020241 NP_065625
Location (UCSC) Chr 5:
149.82 – 149.83 Mb
Chr 18:
60.77 – 60.78 Mb
PubMed search [1] [2]

40S ribosomal protein S14 is a protein that in humans is encoded by the RPS14 gene.[1][2][3]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S11P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. In Chinese hamster ovary cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.[3]

References[edit]

  1. ^ Rhoads DD, Dixit A, Roufa DJ (Jan 1987). "Primary structure of human ribosomal protein S14 and the gene that encodes it". Mol Cell Biol 6 (8): 2774–83. PMC 367844. PMID 3785212. 
  2. ^ Diaz JJ, Roufa DJ (Apr 1992). "Fine-structure map of the human ribosomal protein gene RPS14". Mol Cell Biol 12 (4): 1680–6. PMC 369611. PMID 1549121. 
  3. ^ a b "Entrez Gene: RPS14 ribosomal protein S14". 

Further reading[edit]