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Ribosomal protein S16
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RPS16 ; S16
External IDs OMIM603675 MGI98118 HomoloGene794 GeneCards: RPS16 Gene
Species Human Mouse
Entrez 6217 20055
Ensembl ENSG00000105193 ENSMUSG00000037563
UniProt P62249 P14131
RefSeq (mRNA) NM_001020 NM_013647
RefSeq (protein) NP_001011 NP_038675
Location (UCSC) Chr 19:
39.92 – 39.93 Mb
Chr 7:
28.35 – 28.35 Mb
PubMed search [1] [2]

40S ribosomal protein S16' is a protein that in humans is encoded by the RPS16 gene.[1][2][3]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S9P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3]


RPS16 has been shown to interact with CDC5L.[4]


  1. ^ Batra SK, Metzgar RS, Hollingsworth MA (May 1991). "Molecular cloning and sequence analysis of the human ribosomal protein S16". J Biol Chem 266 (11): 6830–3. PMID 2016298. 
  2. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (August 1998). "A map of 75 human ribosomal protein genes". Genome Res 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194. 
  3. ^ a b "Entrez Gene: RPS16 ribosomal protein S16". 
  4. ^ Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. (ENGLAND) 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529. 

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