40S ribosomal protein S2 is a protein that in humans is encoded by the RPS2gene.
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is co-transcribed with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
^Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID9582194.
^Choi, Seeyoung; Jung Cho-Rok; Kim Jin-Young; Im Dong-Soo (Sep 2008). "PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex". Biochim. Biophys. Acta (Netherlands) 1780 (9): 1062–9. doi:10.1016/j.bbagen.2008.05.010. ISSN0006-3002. PMID18573314.
Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem.239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID8706699.
Kowalczyk P, Woszczyński M, Ostrowski J (2003). "Increased expression of ribosomal protein S2 in liver tumors, posthepactomized livers, and proliferating hepatocytes in vitro". Acta Biochim. Pol.49 (3): 615–24. PMID12422231.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol.14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID15324660.
Antoine M, Reimers K, Wirz W, et al. (2005). "Identification of an unconventional nuclear localization signal in human ribosomal protein S2". Biochem. Biophys. Res. Commun.335 (1): 146–53. doi:10.1016/j.bbrc.2005.07.069. PMID16061210.
Antoine M, Reimers K, Wirz W, et al. (2006). "Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2". Biochem. Biophys. Res. Commun.338 (2): 1248–55. doi:10.1016/j.bbrc.2005.10.079. PMID16263090.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol.24 (10): 1285–92. doi:10.1038/nbt1240. PMID16964243.