From Wikipedia, the free encyclopedia
Jump to: navigation, search
Ribosomal protein S2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RPS2 ; LLREP3; S2
External IDs OMIM603624 MGI105110 HomoloGene37714 GeneCards: RPS2 Gene
Species Human Mouse
Entrez 6187 16898
Ensembl ENSG00000140988 ENSMUSG00000044533
UniProt P15880 P25444
RefSeq (mRNA) NM_002952 NM_008503
RefSeq (protein) NP_002943 NP_032529
Location (UCSC) Chr 16:
2.01 – 2.01 Mb
Chr 17:
24.72 – 24.72 Mb
PubMed search [1] [2]

40S ribosomal protein S2 is a protein that in humans is encoded by the RPS2 gene.[1][2]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is co-transcribed with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[2]


RPS2 has been shown to interact with PRMT3.[3]


  1. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194. 
  2. ^ a b "Entrez Gene: RPS2 ribosomal protein S2". 
  3. ^ Choi, Seeyoung; Jung Cho-Rok; Kim Jin-Young; Im Dong-Soo (Sep 2008). "PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex". Biochim. Biophys. Acta (Netherlands) 1780 (9): 1062–9. doi:10.1016/j.bbagen.2008.05.010. ISSN 0006-3002. PMID 18573314. 

Further reading[edit]